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Recombinant Chicken Ribosomal protein S6 kinase alpha-5 (RPS6KA5), partial

Recombinant Chicken Ribosomal protein S6 kinase alpha-5 (RPS6KA5), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

RPS6KA5

Purity

>85% (SDS-PAGE)

Target Names

RPS6KA5

Uniprot NO.

Q5F3L1

Alternative Names

RPS6KA5; RCJMB04_14g1Ribosomal protein S6 kinase alpha-5; S6K-alpha-5; EC 2.7.11.1

Species

Gallus gallus (Chicken)

Source

Yeast

Expression Region

1-789

Target Protein Sequence

MEGPSGSAQG SEWPLLTVTH ELRNANLTGH AEKVGIENFE LLKVLGTGAY GKVFLVRKVS GHDAGKLYAM KVLKKATIVQ KAKTTEHTRT ERQVLEHIRQ SPFLVTLHYA FQTDTKLHLI LDYINGGELF THLSQRERFS ENEVQIYIGE IVLALEHLHK LGIIYRDIKL ENILLDSDGH VVLTDFGLSK EFLTDENERA YSFCGTIEYM APDIVRGGDT GHDKAVDWWS VGVLMYELLT GASPFTVDGE KNSQAEISRR ILKSEPPYPQ EMSALSKDII QRLLMKDPKK RLGCGPTDAD EIKQHPFFQN INWDDLAAKK VPAPFKPVIR DELDVSNFAE EFTEMDPTYS PAATPQTSEK IFQGYSFVAP SILFKRNAAT VDPVQFYVGD ERPGTTTIAR SAMMKDSPFF QHYELDLKEK PLGEGSFSIC RKCLHKKTSQ EYAVKIISKR MEANTQREIT ALKLCEGHPN VVKLHEVYHD QLHTFLVMEL LKGGELLERI QKKQHFSETE ASHIMRRLVS AVSHMHDVGV VHRDLKPENL LFTDETDNSE IKIIDFGFAR LKPPDNQPLK TPCFTLHYAA PELFNHNGYD ESCDLWSLGV ILYTMLSGQV PFQSQDKSLT CTSALEIMKK IKKGEFSFEG EAWKNVSEEA KELIQGLLTV DPNKRIKMSS LRYNEWLQDG SQLSSNPLMT PDNLGSSGAA VHTYVKATFH AFNKYKREGF CLQNVDKAPL AKRRKMKKTS TSTETRSSSS ESSHSSSSHS HGKTTPTKTL QPTNPTDSNN PETIFQFSD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and that contributes to gene activation by histone phosphorylation. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14).

Subcellular Location

Nucleus.

Protein Families

Protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily

Tissue Specificity

Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver.

Database Links

UNIGENE: Gga.14856

KEGG: gga:423408

STRING: 9031.ENSGALP00000017378

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