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Recombinant Chicken Retinoblastoma-associated protein (RB1), partial

Recombinant Chicken Retinoblastoma-associated protein (RB1), partial

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MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

RB1

Purity

>85% (SDS-PAGE)

Target Names

RB1

Uniprot NO.

Q90600

Alternative Names

RB1; Retinoblastoma-associated protein; p104; pRb; Rb

Species

Gallus gallus (Chicken)

Source

Yeast

Expression Region

1-921

Target Protein Sequence

MPPKPLRRAG AARSQRTSPE GGAGTASPPG GTRLEVGEAE FVALCDALKA PDSVREKAWM TYQSLAAADG ASAYNKKKKE TWGVCIFIVA IDLDEMTFTF TELLKSLSIS VCTFFQFLKE VDVNMDTVST KVDSTVSRLK KKYDVLLALY HKFERTCGLI YLEQPSSEIS AELSSVLVLK NYWITFLLAK GKVLQMEDDL VISFQLLLCV LDYFIKLSPP AMLKEPYKSA VTALTVNGST RTPRRGQNRN ARASKQIDTD TKVIEILCKE HDCNLDEVKN VYFTSFIPFL NSLGVVASNG LPEVDVLSKQ YDELYLKNKD IDARLFLDHD ETLQPDVIAC SQLERTPRKN NPDEEVNHVL PQTPVRAAMN TIQQLMMILN SATDKPSDTL IAYFNNCTVN PEDSILKRVE SLGHIFKKKF AEAVGQGCAE IGSQRYQLGV RLYYRVMESM LKSEEERLSV HNFSKLLNDN IFHTSLLACA LEIVMATYGR TASQSDGTSA ETDLSFPWIL NVFDLKAFDF YKVIESFIKV EPSLTRDMIK HLERCEHRIM ESLAWQSDSP LFDLIKQSKE REGQTDQPEP TSTLNLPLQH NHTAADLYLS PVRSPKKKAS GHPQSGTSNP DAQPSATSQT QKPQKSTSLS LFYKKVFRLA YLRLHTLFFR LLSEHPDLEP LIWTLFQHTL QNESELMRDR HLDQIMMCSM YGICKVKNVD LRFKTIVSAY KELPNTNQET FKRVLIREEQ YDSIIVFYNL VFMQKLKTNI LQYASNRPPT LSPIPHIPRS PYQFSNSPRR VPAGNNIYIS PLKSPYKFSD GFHSPTKMTP RSRILVSIGE TFGTSEKFQK INQMVCNSES HVKRSAEPSD APKPLKRLRF DIEGQDEADG GKHLPQESKF QQKLAEMTST RTRMQKQKLN DGNDTSANEE K
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle. The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes. Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription. Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase. RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C.

Gene References into Functions

Experiments showed an essential role of pRb in S-phase entry of the supporting cells in the damaged neonatal chicken utricle and have shown that the proliferation of these cells requires the phosphorylation of pRb PMID:25100553
the RB1 gene was a major gene for body weight and bone traits PMID:21906182

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Subcellular Location

Nucleus.

Protein Families

Retinoblastoma protein (RB) family

Database Links

UNIGENE: Gga.2986

KEGG: gga:386582

STRING: 9031.ENSGALP00000035706

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