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Recombinant Chicken Repulsive guidance molecule A (RGMA)

Recombinant Chicken Repulsive guidance molecule A (RGMA)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

RGMA

Purity

>85% (SDS-PAGE)

Target Names

RGMA

Uniprot NO.

Q8JG54

Species

Gallus gallus (Chicken)

Source

Yeast

Expression Region

150-404

Target Protein Sequence

P HLRTFTDTFQ TCKVQGAWPL IDNNYLNVQV TNTPVLPGSS ATATSKLTII FKSFQECVEQ KVYQAEMDEL PAAFADGSKN GGDKHGANSL KITEKVSGQH IEIQAKYIGT TIVVRQVGRY LTFAVRMPEE VVNAVEDRDS QGLYLCLRGC PLNQQIDFQT FRLAQAAEGR ARRKGPSLPA PPEAFTYESA TAKCREKLPV EDLYFQSCVF DLLTTGDVNF MLAAYYAFED VKMLHSNKDK LHLYERTRAL APGN
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Acts as an axon-specific repulsive guidance molecule in the retinotectal system. Repulsive for a subset of axons of the temporal half of the retina. Provides thus positional information for the temporal axons invading the optic tectum in the stratum opticum.

Gene References into Functions

C-RGMa activates the Leukemia-associated RhoGEF (LARG)/Rho/Rock pathway to block axonal growth. PMID:26292756
RGMa and RGMb expression pattern during chicken development suggest unexpected roles for these repulsive guidance molecules in notochord formation, somitogenesis, and myogenesis. PMID:23073896
Repulsive guidance molecule is mediated by the action of neogenin. PMID:15258590
Repulsive guidance molecule regulates neuronal survival. PMID:15258591
RGMa overexpression promotes neuronal differentiation, whereas RGMa small interference RNA represses it. PMID:16738252
Repulsive guidance molecule A expression on retinal axons is a major determinant of topographic targeting in the retino-tectal projection and in the retina. PMID:18280178