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Recombinant Chicken Proheparin-binding EGF-like growth factor (HBEGF), partial

Recombinant Chicken Proheparin-binding EGF-like growth factor (HBEGF), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

HBEGF

Purity

>85% (SDS-PAGE)

Target Names

HBEGF

Uniprot NO.

Q9W7C5

Species

Gallus gallus (Chicken)

Source

Yeast

Expression Region

19-167

Target Protein Sequence

AV GKFGRDGPHG EALHNEVLLH EGGGVASVSA TAPLLGGIVE KEGGGAASGD ALSELPRVAF LSKPQGPVTP KKKGNGNKRR KGKGLGKKRD PCLRKYKDFC IHGECKYIRE LGAPSCICQP GYHGERCHGL LLPVEHPPST YDHTTAL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Plays an important role in the proper development of cranial nerves by inhibiting the migration of the cranial neural crest cells (NCCs) into the odd-numbered neuromeres (r3 and r5) of the hindbrain Plays a role in mediating v-Jun-induced oncogenic transformation.

Gene References into Functions

CNIH2 gene facilitated the secretion of HB-EGF in the developing chick brain PMID:17229890

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Subcellular Location

[Heparin-binding EGF-like growth factor]: Secreted, extracellular space.; [Proheparin-binding EGF-like growth factor]: Cell membrane; Single-pass type I membrane protein.

Database Links

UNIGENE: Gga.389

KEGG: gga:395654

STRING: 9031.ENSGALP00000001399

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