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Recombinant Chicken Progesterone receptor (PGR), partial

Recombinant Chicken Progesterone receptor (PGR), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

PGR

Uniprot NO.

P07812

Species

Gallus gallus (Chicken)

Source

Yeast

Expression Region

1-786

Target Protein Sequence

MTEVKSKETR APSSARDGAV LLQAPPSRGE AEGIDVALDG LLYPRSSDEE EEEEENEEEE EEEEPQQREE EEEEEEEDRD CPSYRPGGGS LSKDCLDSVL DTFLAPAAHA APWSLFGPEV PEVPVAPMSR GPEQKAVDAG PGAPGPSQPR PGAPLWPGAD SLNVAVKARP GPEDASENRA PGLPGAEERG FPERDAGPGE GGLAPAAAAS PAAVEPGAGQ DYLHVPILPL NSAFLASRTR QLLDVEAAYD GSAFGPRSSP SVPAADLAEY GYPPPDGKEG PFAYGEFQSA LKIKEEGVGL PAAPPPFLGA KAAPADFAQP PRAGQEPSLE CVLYKAEPPL LPGAYGPPAA PDSLPSTSAA PPGLYSPLGL NGHHQALGFP AAVLKEGLPQ LCPPYLGYVR PDTETSQSSQ YSFESLPQKI CLICGDEASG CHYGVLTCGS CKVFFKRAME GQHNYLCAGR NDCIVDKIRR KNCPACRLRK CCQAGMVLGG RKFKKLNKMK VVRTLDVALQ QPAVLQDETQ SLTQRLSFSP NQEIPFVPPM ISVLRGIEPE VVYAGYDNTK PETPSSLLTS LNHLCERQLL CVVKWSKLLP GFRNLHIDDQ ITLIQYSWMS LMVFAMGWRS YKHVSGQMLY FAPDLILNEQ RMKESSFYSL CLSMWQLPQE FVRLQVSQEE FLCMKALLLL NTIPLEGLRS QSQFDEMRTS YIRELVKAIG LRQKGVVANS QRFYQLTKLM DSMHDLVKQL HLFCLNTFLQ SRALSVEFPE MMSEVIAAQL PKILAGMVKP LLFHKK
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Gene References into Functions

The results indicate that PR percentage and the PR-A and PR-B ratio change according to the cell type of the oviduct magnum and in an age-specific manner. PMID:27526993
Data suggest that progesterone receptors A (PRA) and B (PRB) and progesterone receptor membrane component 1 (PGRMC1) are expressed in neurons of embryonic dorsal root ganglia. PMID:23913445
Content of progesterone receptor (PR)isoforms related to degree of brain development in chicks PMID:14511763
a portion of the cytoplasmic receptor is seen as an oligomeric complex, whereas, in the nucleus, most, if not all receptor molecules are in dissociated form PMID:14514410
In Estrogen receptor-/PR- breasst tumors in age > 50, ER+/PR+ status was associated with higher frequency of methylation. PMID:15041725
Collectively, elevated circulating estrogen and/or decreased progesterone levels may have contributed to the upregulation of PGR mRNA and isoforms A and B in the pituitary gland of restricted ovulator hen, which have a point mutation in VLDLR. PMID:16677794
Results demonstrate that PR isoforms content presents a sexual dimorphism in the brain of chickens that changes in tissue- and age-specific manner, and suggest that these variations contribute to the regulation of progesterone actions in brain. PMID:17141234
A side-by-side comparison of the Hsp90-dependent chaperoning of Chk1 to that of the progesterone receptor (PR) was performed to show that these distinct types of clients have different chaperoning requirements. PMID:18229454