Recombinant Chicken Paxillin (PXN), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

PXN

Uniprot NO.

P49024

Alternative Names

PXNPaxillin

Species

Gallus gallus (Chicken)

Source

Yeast

Expression Region

1-559

Target Protein Sequence

MDDLDALLAD LESTTSHISK RPVFLTEETP YSYPTGNHTY QEIAVPPPVP PPPSSEALNG TVIDPLDQWQ PSVSRYGHQQ PQSQSPIYSS SAKSSSASVP RDGLSSPSPR ASEEEHVYSF PNKQKSAEPS PTMTSTSLGS NLSELDRLLL ELNAVQHNPP SGFSADEVSR SPSLPNVTGP HYVIPESSSS AGGKAAPPTK EKPKRNGGRG IEDVRPSVES LLDELESSVP SPVPAITVSQ GEVSSPQRVN ASQQQTRISA SSATRELDEL MASLSDFKFM AQGKAGGSSS PPSTTPKPGS QLDTMLGSLQ SDLNKLGVAT VAKGVCGACK KPIAGQVVTA MGKTWHPEHF VCTHCQEEIG SRNFFERDGQ PYCEKDYHNL FSPRCYYCNG PILDKVVTAL DRTWHPEHFF CAQCGVFFGP EGFHEKDGKA YCRKDYFDMF APKCGGCARA ILENYISALN TLWHPECFVC RECFTPFING SFFEHDGQPY CEVHYHERRG SLCSGCQKPI TGRCITAMGK KFHPEHFVCA FCLKQLNKGT FKEQNDKPYC QNCFLKLFC
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the SH2 domain of v-CRK.

Gene References into Functions

Data suggest that the first LD motif (LD1; leucine-rich motif) of paxillin binds to the CCHD (C-terminal region of Cas family homology domain) of p130Cas/Bcar1 (in a 1:1 stoichiometry with Kd approximately 4.2 uM); p130Cas/Bcar1 CCHD is stabilized by forming complex with paxillin LD1; these studies utilized chicken paxillin and mouse p130Cas/Bcar1. (p130Cas/Bcar1 = breast cancer anti-estrogen resistance protein 1) PMID:28860193
Data indicate that chicken paxillin leucine-aspartate LD2 and LD4 motifs preferentially dock at the helix 2/3 binding site of human Proline-rich tyrosine kinase 2 (Pyk2)-focal adhesion kinase (FAK). PMID:25174335
Phosphorylation of paxillin LD4 results in a reduction of binding affinity to FAK. PMID:18092823

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Subcellular Location

Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cytoplasm, cell cortex.

Database Links

UNIGENE: Gga.4056

KEGG: gga:395832

STRING: 9031.ENSGALP00000011713

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