Recombinant Chicken Noggin (NOG)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

NOG

Uniprot NO.

O93525

Alternative Names

NOG; Noggin; cNoggin

Species

Gallus gallus (Chicken)

Source

Yeast

Expression Region

27-223

Target Protein Sequence

QHYL HIRPAPSDNL PLVDLIEHPD PIFDPKEKDL NETLLRSLMG GHFDPNFMAM SLPEDRLGVD DLAELDLLLR QRPSGAMPGE IKGLEFYDGL QPGKKHRLSK KLRRKLQMWL WSQTFCPVLY TWNDLGSRFW PRYVKVGSCY SKRSCSVPEG MVCKPAKSVH LTILRWRCQR RGGQRCTWIP IQYPIIAECK CSC
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Inhibitor of bone morphogenetic proteins (BMP) signaling. Controls somitogenesis by sequestering the BMP-4 activity which in turn differentiates distinct subtypes of the mesoderm along the mediolateral axis.

Gene References into Functions

Noggin overexpression resulted in disrupted cord organization, and dilated sinusoidal space, eventually leading to increased apoptosis and failed hepatocyte differentiation. PMID:26173507
The expression level of Noggin (together with other cartilage expressed BMP antagonists) is a landmark in the transition between the chondrogenic and fibrogenic response to BMPs in the differentiation of connective tissues. PMID:24038612
Study demonstrates that MyoD expressing cells serve as a Noggin delivery system to regulate the morphogenesis of the lens and optic cup. PMID:19778533
Noggin and Shh are both required in order to change the future amnion into a feather-bearing skin. PMID:15269169
Noggin overexpression inhibits G1/S transition and blocking G1/S abrogates Bone Morphogenetic Proteins-induced delamination; moreover, transcription of Wnt1 is stimulated by BMP and by the developing somites PMID:15456730
results show that inhibition of BMP4 by noggin results in a reduction of embryonic blood vessels PMID:15766751
In Noggin -/- embryos, the gross anatomy of the inner ear is distorted and malformed, with cochlear duct outgrowth and coiling most affected. PMID:17900554
increased Bmp4-Wnt1 signaling through Nog inhibition in the caudal-most NT at E4/HH24 induces proneurogenic markers in migratory NCCs, suggesting that noggin plays a role in the lack of neurogenic potential characterizing the caudal-most NCCs. PMID:19369402