Recombinant Chicken Netrin-1 (NTN1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

NTN1

Purity

>85% (SDS-PAGE)

Target Names

NTN1

Uniprot NO.

Q90922

Alternative Names

NTN1Netrin-1

Species

Gallus gallus (Chicken)

Source

Yeast

Expression Region

26-606

Target Protein Sequence

GYPGL NMFAVQTAQP DPCYDEHGLP RRCIPDFVNS AFGKEVKVSS TCGKPPSRYC VVTEKGEEQV RSCHLCNASD PKRAHPPSFL TDLNNPHNLT CWQSDSYVQY PHNVTLTLSL GKKFEVTYVS LQFCSPRPES MAIYKSMDYG KTWVPFQFYS TQCRKMYNKP SRAAITKQNE QEAICTDSHT DVRPLSGGLI AFSTLDGRPT AHDFDNSPVL QDWVTATDIK VTFSRLHTFG DENEDDSELA RDSYFYAVSD LQVGGRCKCN GHASRCVRDR DDNLVCDCKH NTAGPECDRC KPFHYDRPWQ RATAREANEC VACNCNLHAR RCRFNMELYK LSGRKSGGVC LNCRHNTAGR HCHYCKEGFY RDLSKPISHR KACKECDCHP VGAAGQTCNQ TTGQCPCKDG VTGITCNRCA KGYQQSRSPI APCIKIPAAP PPTAASSTEE PADCDSYCKA SKGKLKINMK KYCKKDYAVQ IHILKAEKNA DWWKFTVNII SVYKQGSNRL RRGDQTLWVH AKDIACKCPK VKPMKKYLLL GSTEDSPDQS GIIADKSSLV IQWRDTWARR LRKFQQREKK GKCRKA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Netrins control guidance of CNS commissural axons and peripheral motor axons. Promotes neurite outgrowth from commissural axons but acts as a chemorepellent for trochlear motor axons. These effects are mediated by distinct receptors.

Gene References into Functions

Ntn1 may play divergent cellular roles despite its conserved expression during canal morphogenesis in chicken and mouse. PMID:28851705
Data suggest that, in response to netrin-1/netrin receptor (DCC) signaling, p120RasGAP is recruited to growth cones and supports axon outgrowth; p120RasGAP Src homology 2 domains exhibit scaffolding properties sufficient to support axon outgrowth. PMID:26710849
Netrin-1 and integrins interact on growth cones; netrin-1 causes integrin activation PMID:24001590
Proximal tubular epithelial cells may play a prominent role in interstitial fibrosis and that netrin-1 could be a useful therapeutic agent for treating kidney fibrosis. PMID:23408169
Netrin-1-induced suppression of prostaglandin E2 production was mediated through suppression of NFkappaB-mediated cyclooxygenase-2 (COX-2) in renal tubular epithelial cells. PMID:23041393
Study shows acute treatment with two attractive guidance cues, NGF and netrin-1, for embryonic dorsal root ganglion and temporal retinal neurons, respectively, results in increased growth cone membrane protrusion, actin polymerization, and F-actin. PMID:20506164
These results provide evidence that netrin 1 acts as chemoattractant to migrating GnRH neurons at the dorsocaudal part of the septum and has the potential to regulate the ventral migration of GnRH neurons to the ventral septum and the preoptic area. PMID:20394056
Netrin binds through multiple domains to both DCC and Unc5c. PMID:15574733
Netrin-1 raises the frequency of repetitive Ca2+ transients. This involve release from intracellular stores. Ca2+ signaling is essential for netrin-1-induced axon branching. CaMKII & MAPK are the major downstream targets & are needed for axon branching. PMID:16014732
Data show that Netrin-1 expressing cells inhibited angiogenic sprouting of unc5b expressing blood vessels, but had no pro-angiogenic activity at any stage of development examined. PMID:18439993
netrin-1 protects renal tubular epithelial cells against ischemia reperfusion-induced injury by increasing proliferation and suppressing apoptosis PMID:19700747