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Recombinant Chicken Interferon regulatory factor 3 (IRF3)

Recombinant Chicken Interferon regulatory factor 3 (IRF3)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

IRF3

Purity

>85% (SDS-PAGE)

Target Names

IRF3

Uniprot NO.

Q90643

Alternative Names

IRF3Interferon regulatory factor 3; IRF-3

Species

Gallus gallus (Chicken)

Source

Yeast

Expression Region

1-491

Target Protein Sequence

MAALDSEGDA QKLRFGPWLL NAVSSGLYRG LCWIDPDRRI FRIPWKHNAR KDVTSSDVEI FKAWAKASGR YEGNAEDPAK WKTNFRCALR STHMFMLLED RSKCNDDPHK VYAVASGVPN DRGSGGPVAG ALQQQPQLLL NHHDLALENT PTDSTEGVAA AALTQVDLDL LQSVLQHCNI SALGSQPTLW AHTGDALPED ALLLPGQDGC LPGPQFQDWR QLEEPLLLGN QPLTGGGCGQ DGAGALPVSE ECAIPAPSPA EELLFQSANP APPPPAGDIG GLPPLLDITI YYRGKMVYQE QVDDSRCVLA YQPLDPAVAE QRLVLFPSPA SLPDPRQRRY TEDLLEVAGL RLEQRAGQLL ATRLKKCKVF WALSQQLEGG EPPLNLLHRD QETTIFDFRV FCTELRDFRD SRRERSPDFT IFLCFGQCFS STKPKESKLI LVKLVPQFCE YWYEQVQRGG ASSLNSGNVS LQLSDSFNLF ELIEQYHMQT D
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the IRF-1 binding site PRD-I.

Gene References into Functions

chTBK1 may be an important immunoregulator for IRF3 and IFNbeta induction in response to viral stimulation in chicken. PMID:28493975
IRF7 may have conserved functional activity in the avian antiviral response, and plays a crucial role in type I IFN regulation. PMID:26186542

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

IRF family

Tissue Specificity

Widely expressed with higher expression in lung, spleen and intestine.

Database Links

UNIGENE: Gga.1087

KEGG: gga:396330

STRING: 9031.ENSGALP00000023072

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