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Recombinant Chicken Insulin-like growth factor 2 (IGF2)

Recombinant Chicken Insulin-like growth factor 2 (IGF2)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

IGF2

Uniprot NO.

P33717

Alternative Names

IGF2Insulin-like growth factor II; IGF-II

Species

Gallus gallus (Chicken)

Source

Yeast

Expression Region

24-91

Target Protein Sequence

AYGTAET LCGGELVDTL QFVCGDRGFY FSRPVGRNNR RINRGIVEEC CFRSCDLALL ETYCAKSVKS E
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Buffer

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling.

Gene References into Functions

we found that MYOD transcription factor can upregulate miR-223 expression by binding to an E-box region of the gga-miR-223 gene promoter during avian myoblast differentiation. IGF2 and ZEB1 are two target genes of miR-223 PMID:28981085
IGF1 and IGF2 might separately be more important for muscle and liver growth in chick embryonic development. Variation of IGFs expression during the incubation might be concerned with the methylation of gene promoter. PMID:26944971
These findings implied that polymorphisms within IGF1 and IGF2 genes could be in linkage disequilibrium with the actual causative mutations that affect growth and carcass traits. PMID:20379887
IGF2 is a candidate gene influencing growth and carcass traits, and has biallelic expression. PMID:15986892
These results suggest that the mechanism of action whereby IGFBP2 excess impairs long bone development is to inhibit IGF-I and IGF-II-mediated proliferation and matrix synthesis. PMID:16183342
These findings provide the first evidence for a potential role of the insulin-like growth factor II-vitronectin complex during the endothelial-to-mesenchymal transition process. PMID:16831197
Blood levels of IGF-II may be a more important functionary for chick embryonic development than IGF-I. PMID:17369538