Recombinant Chicken Indian hedgehog protein (IHH)

Baculovirus
Mammalian cell

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

IHH

Purity

>85% (SDS-PAGE)

Target Names

IHH

Uniprot NO.

Q98938

Alternative Names

IHH; Indian hedgehog protein; IHH) [Cleaved into: Indian hedgehog protein N-product; Indian hedgehog protein C-product]

Species

Gallus gallus (Chicken)

Source

Yeast

Expression Region

24-408

Target Protein Sequence

CGPGRVV GSRRRPPRKL IPLAYKQFSP NVPEKTLGAS GRYEGKIARN SERFKELTPN YNPDIIFKDE ENTGADRLMT QRCKDRLNSL AISVMNQWPG VKLRVTEGWD EDGHHSEESL HYEGRAVDIT TSDRDRNKYG MLARLAVEAG FDWVYYESKA HIHCSVKSEH SAAAKTGGCF PGRALATLEN GARTPLWALR PGQRVLAMDG AGRPTYSDFL AFLDKEPRAL TAFHVIETRQ PPRRLALTPT HLLFVADNAS APAAQFRPTF ASHVQPGHFV LVAVGSGGLQ PAEVVGVRGR TDVGAYAPLT RHGTLVVDDV VASCFALVRE QQLAQMAFWP LRLYHSLLGG PGVQGDGVHW YSGLLYRLGR MLLPPDSFHP LGAPRAES
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP).

Gene References into Functions

Based on these results, the Ihh signal is essential for balancing chicken chondrocyte proliferation and hypertrophy, and the regulatory function of PTHrP acts in an Ihh-dependent manner. PMID:23928032
Reduction of Ihh in chicken embryo hindlimbs reduced skeletal muscle mass similar to that seen in Ihh(-/-) mouse embryos PMID:21683695
BMPs are integrated into the Ihh/PTHrP signaling loop, and a fine balance of BMP signaling is essential for normal chondrocyte maturation and skeletal development. PMID:12968668
Indian hedgehog and syndecan-3 have roles in chondrocyte proliferation and limb skeletogenesis PMID:14991716
IHH and FGF8 maybe play different roles and act synergistically to promote chondrogenesis during digit primordia elongation. PMID:17889828

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Subcellular Location

[Indian hedgehog protein N-product]: Cell membrane; Lipid-anchor; Extracellular side.; [Indian hedgehog protein C-product]: Secreted, extracellular space.

Protein Families

Hedgehog family

Tissue Specificity

Expressed in developing midgut, lung and cartilage of developing long bones in the limb.

Database Links

UNIGENE: Gga.473

KEGG: gga:395801

STRING: 9031.ENSGALP00000018493

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