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Recombinant Chicken Hypoxia-inducible factor 1-alpha (HIF1A), partial

Recombinant Chicken Hypoxia-inducible factor 1-alpha (HIF1A), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

HIF1A

Purity

>85% (SDS-PAGE)

Target Names

HIF1A

Uniprot NO.

Q9YIB9

Species

Gallus gallus (Chicken)

Source

Yeast

Expression Region

1-811

Target Protein Sequence

MDSPGGVTDK KRISSERRKE KSRDAARCRR SKESEVFYEL AHQLPLPHTV SAHLDKASIM RLTISYLRMR KLLDAGELET EANMEKELNC FYLKALDGFV MVLSEDGDMI YMSENVNKCM GLTQFDLTGH SVFDFTHPCD HEELREMLTH RNGPVKKGKE QNTERSFFLR MKCTLTSRGR TVNIKSATWK VLHCTGHIRV YDTCNNQTHC GYKKPPMTCL VLICEPIPHP SNIEVPLDSK TFLSRHSLDM KFSYCDERIT ELMGYEPEEL LGRSIYEYYH ALDSDHLTKT HHDMFTKGQV TTGQYRMLAK QGGYVWVETQ ATVIYNTKNS QPQCIVCVNY VLSGIVQKDL IFSLGQTECM LKPVESPEMK MTKIFSKDDW DDTNSLFEKL KQEPDALTVL APAAGDTIIS LDFSSNESDE QQCDEVPLYN DVMLPSSSEK LQNINIAMSP LPASETTKPL RSNADPALNR EVVSKLEPNT ETLELSFTMP QVQEQPTSPS DASTSQSSPE PSSPNDYCFD VDNDMANEFK LELVEKLFAI DTEAKNPFST QETDLDLEML APYIPMDDDF QLRSFDQLSP LESSSSGSQN AATITILQQT QTPSTAADEI KPVAERVDDV KALIVPSSPV HVINDTSSAP ASPYSGNRSR TASPIRAGKG TLEQTEKSCP GAPSLITVTL NKRSTAMDEE LNPKMLALHN AQRKRKMEHD GSLFQAVGIG SLFQQTGDRG GNASLAWKRV KACKTNGHNG VEQKTIILLS TDIASKLLGQ SMDESGLPQL TSYDCEVNAP IQGNRNLLQG EELLRALDQV N
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease.

Gene References into Functions

HIF-1alpha, -2alpha, and -3alpha expressions in the tibial growth plate of Tibetan chickens were upregulated by hypoxia and the change was more significant than in Arbor Acres chickens. PMID:28693310
FK228 (HIF-1alpha inhibitor) significantly (P less than 0.05) down- regulated the mRNA and protein levels of HIF-1alpha and Hsp90, restored the size of growth plate and diminished lameness. In conclusion, HIF-1alpha and Hsp90 play an important role in the formation of avascular growth plate and there is a direct relationship between HIF-1alpha and Hsp90 for the progression of TD pathogenesis PMID:29504370
Altering HIF-1alpha through 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure affects coronary vessel development. PMID:23264063
These findings hinted that HIF-1alpha might be associated with the development of ascites syndrome induced by excess salt in drinking water in broiler chickens. PMID:23873551
Epicardial HIF signaling regulates vascular precursor cell invasion into the myocardium PMID:23384563
HIF-1alpha induction during hypoxic preconditioning is necessary to obtain enhanced HIF-1alpha accumulation and to develop tolerance against a subsequent hypoxic injury. PMID:21953610
Data suggest that developing coronary vessels may be subject to a level of regulation that is dependent on differential oxygen levels within cardiac tissues and subsequent HIF-1alpha regulation of gene expression. PMID:19777592
Results showed that HIF-1alpha mRNA displayed tissue specific differential expression, with the highest in the brain PMID:17284428
This study found that tissue hypoxia is likely a normal component of embryonic development in the chicken based on the upregulation of hypoxia response genes. PMID:17954589
Hypoxia signaling through HIF-1 and VEGF provides an autocrine survival signal in the developing cardiac output flow tract[OFT] and that perturbation in this pathway causes OFT defects that model congenital human conotruncal heart defects. PMID:18467628