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Recombinant Chicken Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1), partial

Recombinant Chicken Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

HS2ST1

Purity

>85% (SDS-PAGE)

Target Names

HS2ST1

Uniprot NO.

Q76KB1

Species

Gallus gallus (Chicken)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes.

Gene References into Functions

Molecular mechanism of substrate specificity for heparan sulfate 2-O-sulfotransferase. PMID:24652287
study showed that one heparan sulfate 2-O-sulfotransferase (HS2ST) and two isoforms of heparan sulfate 6-O-sulfotransferase (HS6ST-1 and -2) occurred in chick embryos and showed where the transcripts were distributed throughout the limb bud PMID:14660620
Results report the homotrimeric crystal structure of 2OST from chicken, in complex with 3'-phosphoadenosine 5'-phosphate, and identify amino acid residues that are responsible for substrate specificity. PMID:19022906

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Subcellular Location

Golgi apparatus membrane; Single-pass type II membrane protein.

Protein Families

Sulfotransferase 3 family

Tissue Specificity

Expressed in heart, limb, head and trunk. At stages 20 and 24, it is expressed in the most regions of the first and second pharyngeal arche. In both wing and leg buds, it is detected at the overlying ectoderm and mesenchyme throughout stages 21, 23 and 24

Database Links

UNIGENE: Gga.9290

KEGG: gga:395140

STRING: 9031.ENSGALP00000010096

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