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Recombinant Chicken Growth hormone receptor (GHR), partial

Recombinant Chicken Growth hormone receptor (GHR), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

GHR

Uniprot NO.

Q02092

Alternative Names

GHR; Growth hormone receptor; GH receptor; Somatotropin receptor

Species

Gallus gallus (Chicken)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway.; The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

Gene References into Functions

the molecular mechanisms underlying growth hormone receptor (GHR) in Sex-linked dwarf chickens, was examined. PMID:27819736
GHR mRNA was expressed in all examined oviductal segments with a significantly lower level in the infundibulum in comparison to other parts of the oviduct; specific GHR immunoreactivity was also detected in the wall of the oviduct. PMID:24279179
Between 3 and 6 wk of age, growth hormone receptor expression increased with age in adipose tissue. PMID:22560177
There is a critical miRNA, let-7b, involved in the regulation of GHR. PMID:22781587
Pectoralis major muscle GHR mRNA was greater in line of low weight than high weight selected chicken. PMID:21500111
These results support the possibility that GH acts as a local growth factor during early embryonic development of the visual system. PMID:17618059
The expression of GHR gene was more than 3-fold higher in dwarf chickens, compared with that of the normal. PMID:17681929
Growth hormone (GH) receptor mRNA was also detected within cells of the E7 retinal ganglion cells (RGC) layer and GH receptor protein colocalized with GH in RGC axons. PMID:19213842

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Subcellular Location

Cell membrane; Single-pass type I membrane protein. Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway.

Protein Families

Type I cytokine receptor family, Type 1 subfamily

Tissue Specificity

Broad specificity.

Database Links

UNIGENE: Gga.9233

KEGG: gga:408184

STRING: 9031.ENSGALP00000032222

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