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Recombinant Chicken Fibroblast growth factor 8 (FGF8)

Recombinant Chicken Fibroblast growth factor 8 (FGF8)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

FGF8

Purity

>85% (SDS-PAGE)

Target Names

FGF8

Uniprot NO.

Q90722

Alternative Names

FGF8Fibroblast growth factor 8; FGF-8; Heparin-binding growth factor 8; HBGF-8

Species

Gallus gallus (Chicken)

Source

Yeast

Expression Region

23-214

Target Protein Sequence

QVTVQSPP NFTQHVREQS LVTDQLSRRL VRTYQLYSRT SGKHVQILDN KKINAMAEDG DVHAKLIVET DTFGSRVRIK GAATGFYICM NKKGKLIGKS NGKGKDCVFT EIVLENNYTA LQNAKYEGWY MAFTRKGRPR KGSKTRQHQR EVHFMKRLPK GHQTTEPHRR FEFLNYPFNR RSKRTRNSSA SLRP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs.

Gene References into Functions

a precise and dynamic expression pattern of fibroblast growth factor 8 (Fgf8) was found in the high acuity area anlage, which was regulated by enzymes that degrade retinoic acid (RA). PMID:28648799
FGF8 acts as a binary switch that distinguishes tubular elongation from lumen formation. PMID:26130757
Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules PMID:23201021
Data show that ectopic FGF8 overexpression in the ventral pharynx of HH16-18 embryos caused a dramatic increase in thickness of the mesenchyme. PMID:21419761
sufficient, but not necessary, for ANTXR1 expression in Hamburger and Hamilton stage 18 facial mesenchyme PMID:20034073
FGF8 regulates embryonic limb development via WNT/b-catenin signaling PMID:11290326
When Irx2 is misexpressed with Fgf8 in the chick midbrain, the midbrain develops into cerebellum in conjunction with repression of Otx2 and induction of Gbx2. Signaling by FGF8 modulates the activity of Irx2 by phosphorylation. PMID:15133517
Fgf8 has a role in activating the Ras-ERK pathway and differentiation of cerebellum PMID:15294862
FGF8 and Shh have strong synergistic effects on chondrogenesis in vitro and promote outgrowth and chondrogenesis in vivo, suggesting a very specific role in producing elongated beak structures during chick facial development. PMID:15302603
Fgf8 plays a critical upstream role in an FGF signaling cascade required for otic induction PMID:15741321
genomic structure characterization of chick Fgf8 PMID:16147873
Results show that antagonistic signals from the neural tube and the branchial arches specify extraocular versus branchiomeric muscles, and that Fgf8 is the branchial arch derived signal. PMID:16775000
FGF8 triggered apoptosiss allow the formation of a roof plate progress zone at some distance from the FGF8 source. PMID:16818448
Cross-regulatory interactions between Fgf8 and Shh in the avian frontonasal prominence PMID:17988255
FGF8b acts on the epiblast synergistically with Nodal at the pregastrula stage to induce smooth-muscle actin. It is likely that FGF8b is a candidate molecule secreted by hypoblast and regulates the heart mesoderm formation/early cardiomyogenesis. PMID:18312428