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Recombinant Chicken Double-strand break repair protein MRE11 (MRE11), partial

Recombinant Chicken Double-strand break repair protein MRE11 (MRE11), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

MRE11

Purity

>85% (SDS-PAGE)

Target Names

MRE11

Uniprot NO.

Q9IAM7

Alternative Names

MRE11; Double-strand break repair protein MRE11; EC 3.1.-.-

Species

Gallus gallus (Chicken)

Source

Yeast

Expression Region

1-700

Target Protein Sequence

MSAVSLQDDE DTFKILIATD IHLGYLEKDA VRGNDTFVTF NEILEHAQKN EVDFILLGGD LFHENKPSRK TIHTCLESLR KYCMGDRPVS FEVLSDQAVN FQLSKFPWVN YQDENLNIFM PIFSIHGNHD DPTGVDALCA LDILSCAGLL NHFGRSTSVE KIDISPILLR KGRTKIALYG LGAIPDERLY RMFVNKQVTM LRPKEDEDSW FNMFVIHQNR SKHGATNYIP EQFLDDFINL AVWGHEHECK ITPAQNEQQH FYVTQPGSSV VTSLSPGEAV KKHIGLLRVK GKKMKMQRIA LETVRTFYME DVVLADHPEL FNPDNPKVTQ AIQAFCMEKV EMMLDNAERE RLGNPRQPQK PLIILRVDYT GGFEPFIVHR FSQKYMDRVA NPKDIIHFFR HREQKEKNDN DINFGKLLSR PASEEVTLRV EDLVKQYFQT AEKKVQLSLL TERRMGEAVQ EFVDKEEKDA IEELVKFQLE KTQRFLKERH IDAEEEKIDE EVRKFRESRR KNTEEEDEEV REAMTRARAH RSEGVVLDSA SSDEGLMDTG MKASGDSDDD IPTTLSRGRG RGRARGARGQ NSAARGSSRR GRGNTSQGSS TSSRTYKSVP DKNSSIMDAF RSLKPEPSQS TSKFFSEDII DDEMDLEESP ISLSSKTNQR SSAMSSFSKR GSQSQMSRGV DFESDEDDPF KNTATSRRKK
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.

Gene References into Functions

Both the genome instability and cell death of MRE11-null and MRE11-mutated H129N cells are significantly reversed by overexpression of Tdp2, an enzyme that eliminates covalent Top2 conjugates; thus, the essential role of Mre11 nuclease activity is likely to remove the DNA lesions. PMID:27814490

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Subcellular Location

Nucleus.

Protein Families

MRE11/RAD32 family

Database Links

UNIGENE: Gga.3157

KEGG: gga:395555

STRING: 9031.ENSGALP00000035634

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