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Recombinant Chicken DNA-dependent protein kinase catalytic subunit (PRKDC), partial

Recombinant Chicken DNA-dependent protein kinase catalytic subunit (PRKDC), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

PRKDC

Purity

>85% (SDS-PAGE)

Target Names

PRKDC

Uniprot NO.

Q8QGX4

Alternative Names

PRKDC; XRCC7; DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; EC 2.7.11.1

Species

Gallus gallus (Chicken)

Source

Yeast

Expression Region

1-4134

Target Protein Sequence

MAGGVQECLQ ELHGCLQPGD AMRGYGLLRG LGEACLTCLA GGALALHVSL VFAPERGLLA FVCRSLGVEE FRECREEALK FLCVFLERIG ERAHPYACSL KQTCISVYTK ERAAKCKIPA LELLIKLLQS LRRSCLMEEM KVGEIFNKFY GELAVRSKIS DTVLEKIYEL LGVLGEVHPA DMINNSEKLF RAYLGELKTQ MTSATRVPKL PIVAGCLRGL TALMYNFTKS VDEDAQTSKE IFDFAVKAIR PQVDQKRYAV HLAGLQLFSW HAAQFGTLLL DSYVMLFETM CRWCGHTNQE LKKAGHNALD SFLKQMSLMV AKDAELHKSK LKFFMEQFYG IIRRMDSSNK ELSIAIRGYG LFAAPCKAMH PADVDAMYIE LLQRCKQMYL TEAETIDDHL YQLPSFLQSI ASVIFHLDTI PEVYTPVLEH LVVLQINSFP RYSEKMQLVC CRSIIKVFLA LSIKGPVLWN FISTVVHQGL IRVFSKPMKF SKDVFGKETS GSEEFPESGE VDTARWKVPT YKDYLYLFRS LLSCDTMKES IFEEENFLTG NSPLQSLNRL LYDELIKSIL KIIEKLDLTV QKLNVHEQDE NETDSAFIGP TSDPASNLQP KKPTDFIAFI NLVEFCRDIL PDKHVEYFQP WVYSFGYELI IHSTRLPLIS GFYKLLSVTM KIAKKIKYFE GVGPKSLRKA TEDPEKSSCF ALFAKFGKEV TAKMKQYKDE LLASCLNFLL SLPHDIVMLD IKAYIPALQN AFKLGLSCTP MADLGLDALE DWSAHIPRHI MQPYYKDVLP LLDGYLKNSA TTVEPQNNWE VRKLSRAAQK GFNKIVIQRL RKAKTSSLDD NPSLEAVRTR VARLLGSLGG QINHNLITAT SAEEMMKKCV SWDTKNHLSF AVPFADMKPV IYLDVFLPRV TDLALSASDR QTKIAACELL HSIVAYMLGK ASQMPERQQG PPPMHQLYKR IFPVLLRLAC DVDQVTRQLY EPLVMQLIHW FTNNKKFESQ DTVTFLEAIL SGIVDPVDST LRDFCGQCVR EFLKWSIKQT TPKQQEKSPA NTKSLFKRLY SLALHPSAFK RLGAALAFNS IYREFREENS LVEQFVFEAL VVFLESLALT HTDEKSLGTT QQCCDAINHL KRIIKHKAPA LNKEGKRRVP RGFPATKSVC LQDVVMWLLV QCGRPQTECR HKAMELFYEF VPLLPGNNSP SSWLADVLKK RDVSFLINKF EGGGSDAKSP SGILSQPTLR DMQEPFSLLT VMRWMDMFLA ALDCYNTFFE LRMIKPHEIL GVNERSSFLE AVDFFLETIA LHDIHAAEQC FDCRSRGNIF SPQEREVYNY SKCTIIVRIM EFVTMILEIC QQDFWKLLEK ELLNANFIEL LVMTVCDPSH IGFNTADVQV MKNLPDISVR LLKALMKSPY KEYLQLCLKK RITPQSFEDL CSVDLFNSDA RFDQVRFSAV LSACKQLQKS GLLHSVLHSQ DERPHPSIGS KLLSVVYKSI APGSERSSLP AVDISSKRLA DRLLQLAFAI DDQCEELVSL LLNTVVLSVP LSKASERNFV DFSHGQYFYS LFSDTINQQL LKNLDVIVIH LMESSVSNPQ MVGSILNGML DQSFRERTIR KQQGVKLVTA VLRNWKRLDS WWAKDSSPES KMAVLTLLAK VLQIDSSVSF NTSHEAFTAV FDTYTSLLTD QNLGLNLKGH AVIILPFFTN LSGEKLHDLK NALDQLVAFN FPMSSDEFPK GTLKHNNYVD CTKKFLDALE LSQSPMLLQL MTEVLCRDHR HSMEDLFQAS FKRISRRSST DKQVVLLDTV HKMFQNEDLL SNIVRQAFVD RSLLTLMSHC SLDALREFFC KIIVQAMDTL NSRFTKSNEC VFDTQITKKM GYYKMLEVMY IRLSKDDVHS KDSKINQAYR GSVSVEGNEL TKALIKLCYD AFTENMAGEN QLLEKRRQYH CAAYNCAIAV ISCVFTESKF YQGFLFTEKS EKNLLIFENL IDLKRQYVFP VEIEVPLERK KRYIAIRKEA REAWNDGQDE PKYLASASYM MDSSLSEEMS QFDFSTGVQG FSYSSQDVTA SSAHFRRKET SEYMVLNDEM ELEMDELNQH ECMAPLTTLI KHMQRNQITP KVEEGVIPVD LPLWMKFLHS KLGNPSVPLN IRLFIAKLIV NTEDVFRPYA KQWLGPMLQL VVSGDNGGEG IHYMVVEIAV TVLSWTSVTT PKGNIKDEIL ANRLLEFLMK NAFHQKRAVF RHNLEIIKTV IECWKNCLSI PYSLIFEKFS SGDPDTKDNS VGIQLLGIVL ANNLPPFDLK CEIDRVRYFQ ALVSNMGLLR YKEVYAAAAE VLGLALQYIA ERQNILEDPV YDCVIKQLKR HQNTQQDKFI ICLNKVVKNF PPLADRFMNA VFFLIPKLHG VMKNYCLEVI MCRAEEIPDL YLQLKSKDFI QIMKHRDDER QRVCLDIIYK MLSTLKPPEL KELLPGVTGF ISHPSVICRQ RMYDILMWIY DNYSDPESQA DGDSQEVLSL AKEILLQGLI DENAELQLIV RNFWSDETRL PANILDRMLM LLNSLYSAKI ETQYLSLITN FLLEMTSKSP DYSRKIFEHP LSECKFHDFV IDSSWRYRST MLTPMFVETQ ASQSTNRNSS QERSLSISGS VGGRVRATQR QYEFTPTQNV SGRSSFNWLT GNSIDTLAEY TVPSSSESLS SSMLLVNKRS EKFKQAAFKP VGPDFGKKRL SLPGDKVDSK TKGIDERAEI LRLRRRFLKD QEKVSLIYAR KGVAEQKREK EMKSELKMKF DGQVTLYRSY RVGDLPDIQI EHCSLIAPLQ GLAQKDPTFA KQLFSSLFGG IFCEVKKSKI PSEKKAIIQK LLKDFNHFLS TSVSYFPPFI ACIQEISYKH RELLELDSAN VSTSCLASLQ QPVGILLLEH ALMALSPAEE PPSKRMRGRT ELPPDVVKWL ELAKLYRSLG DYDVLRGIFS GKIGTKDITQ QALLAEARSD YAEAAKCYDE ALSKEDWEDG EPTEAEKDFW ELASLECYDH LTEWKSLEYC ATVNIDSGKP PDLNKTWSDP FYQETYLPYI IRSKLKLLLN GENDQTLLTF IDEAMKTEQK KALIEMHYSQ ELSLLYILQD DFDRAKYYIG NGIQIFMQSY SSIDTLLYQS RMSKLQSVQA LTEIQDFINF MTKTSNIASQ AKSLKRLLRT WTSRYPDAKM DPMNIWDDII TNRCFFLDKL QEKFLCDKAN DSMEVDEESS VGDQMEVDQQ DEDIHSMIRS CKFNMKLKMI ESARKQNSFS IAKKLLKGLR REAKTREDWL VRWNYAYCRF VHSCSQSQSC PERVLSVLKT ISLLEDTKSD YLNKNIMAFR NQNLLLGTTY HIMANALSQD PKCCEQIEEE KTGKILELSG ESSESPEKIL AGLNKRAFQC FSSAARKSEE EVQSLSMEHV DVKGVIDAYM TLVGFCDQHL RKEEEGSLEI NAADLQLFPA IVVEKMIKAL KLNSREARLR FPRLLQIIER YPAETLGLVT RELPSVPCWQ FIGWISQMMA LLDKDEAVAV QHTVEEIVDT YPQAIIYPFT ISSESYCFKD TAAGCRNKEF VASIKNKLDR GGVVQDFIHA LEQLSNPVML FKDWVADVRN ELVKTQRNKI ILKEMYEGMY KNLGDVKAPG LGWLRKRFVQ AFGKDFDSHF GKGGSKLLDM KISDFNEITT ALLTKMNKTH KEPGNLKECS PWMSEFRAEF LRNELEVPGQ YDGKGKPLPE YHVKISGFDE RIMVLESLRK PKRITIRGSD EQEHPFLVKG GEDLRQDQRI EQLFDVMNIV LSRDAACSQR NMQLKTYQVI PMTTRLGLIK WLENTCTLKE FLRNSMTEEE DANYNSLKGP RAAYSDWLSK MGGKAQGLSR YNAMYKNASR TETVIAFKSR ESSVPEDLLR RAFVKMSTSP EAFLALRSHF VSSHALMCVS HWILGIGDRH LSNFMINKET GGMVGIDFGH AFGSATQFLP VPELMPFRLT RQFVNLMMPV KEWGLIYSVM VHALRAYRAD PDLLISTMDV FVKEPSLDWK NFEQRQLKKG GTWIKEINTA EVNWYPLQKV SYVKRKLTGA NPARITCDEL RLGYEKLPFY NDFAAVARGS ADHNIRAKEP EDRLSEETQV RCLIDQATDP NLLGRVWEGW EPWM
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ. Act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism.

Gene References into Functions