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Recombinant Chicken Cellular tumor antigen p53 (TP53)

Recombinant Chicken Cellular tumor antigen p53 (TP53)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

TP53

Uniprot NO.

P10360

Alternative Names

TP53; Cellular tumor antigen p53; Tumor suppressor p53

Species

Gallus gallus (Chicken)

Source

Yeast

Expression Region

1-367

Target Protein Sequence

MAEEMEPLLE PTEVFMDLWS MLPYSMQQLP LPEDHSNWQE LSPLEPSDPP PPPPPPPLPL AAAAPPPLNP PTPPRAAPSP VVPSTEDYGG DFDFRVGFVE AGTAKSVTCT YSPVLNKVYC RLAKPCPVQV RVGVAPPPGS SLRAVAVYKK SEHVAEVVRR CPHHERCGGG TDGLAPAQHL IRVEGNPQAR YHDDETTKRH SVVVPYEPPE VGSDCTTVLY NFMCNSSCMG GMNRRPILTI LTLEGPGGQL LGRRCFEVRV CACPGRDRKI EEENFRKRGG AGGVAKRAMS PPTEAPEPPK KRVLNPDNEI FYLQVRGRRR YEMLKEINEA LQLAEGGSAP RPSKGRRVKV EGPQPSCGKK LLQKGSD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.

Gene References into Functions

Protein p53 occurs at key stages of development: in the esophagus during the remodeling of esophageal glands, in the proventriculus during the differentiation of the epithelium of the mucosa and in the gizzard during the formation of tubular glands. PMID:24068480
p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes. PMID:21447558
Results suggest that extensive deletions are efficient mechanisms of TP53 inactivation, occurring as early events during the immortalization of v-src-transformed chicken cells. PMID:15723564
An initial down-regulation of p53 allowed the SC-2 cells to bypass senescence. The inactivation of p53, and consequently p21WAF1, likely contributed to the SC-2 cells becoming a fully immortal cell line. PMID:16813656
results suggest that the short form of p53 could play a role in the initiation of apoptosis induced by the chemotherapeutic compound, and that the regulation of its expression may be important for the maintenance of transformation status. PMID:16820712
Nitric oxide-induced cell death operates through p53-independent pathways, including a mitochondrial apoptotic pathway in chick embryo cardiomyocytes. PMID:17630850