Recombinant Chicken Caldesmon (CALD1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

CALD1

Uniprot NO.

P12957

Alternative Names

CALD1; CADCaldesmon; CDM

Species

Gallus gallus (Chicken)

Source

Yeast

Expression Region

1-771

Target Protein Sequence

MDDFERRREL RRQKREEMRL EAERLSYQRN DDDEEEAARE RRRRARQERL RQKEEGDVSG EVTEKSEVNA QNSVAEEETK RSTDDEAALL ERLARREERR QKRLQEALER QKEFDPTITD GSLSVPSRRE VNNVEENEIT GKEEKVETRQ GRCEIEETET VTKSYQRNNW RQDGEEEGKK EEKDSEEEKP KEVPTEENQV DVAVEKSTDK EEVVETKTLA VNAENDTNAM LEGEQSITDA ADKEKEEAEK EREKLEAEEK ERLKAEEEKK AAEEKQKAEE EKKAAEERER AKAEEEKRAA EERERAKAEE ERKAAEERER AKAEEERKAA EERAKAEEER KAAEERAKAE EERKAAEERA KAEKERKAAE ERERAKAEEE KRAAEEKARL EAEKLKEKKK MEEKKAQEEK AQANLLRKQE EDKEAKVEAK KESLPEKLQP TSKKDQVKDN KDKEKAPKEE MKSVWDRKRG VPEQKAQNGE RELTTPKLKS TENAFGRSNL KGAANAEAGS EKLKEKQQEA AVELDELKKR REERRKILEE EEQKKKQEEA ERKIREEEEK KRMKEEIERR RAEAAEKRQK VPEDGVSEEK KPFKCFSPKG SSLKIEERAE FLNKSAQKSG MKPAHTTAVV SKIDSRLEQY TSAVVGNKAA KPAKPAASDL PVPAEGVRNI KSMWEKGNVF SSPGGTGTPN KETAGLKVGV SSRINEWLTK TPEGNKSPAP KPSDLRPGDV SGKRNLWEKQ SVEKPAASSS KVTATGKKSE TNGLRQFEKE P
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping.

Gene References into Functions

the region between residues 627 and 642 may contribute to the overall regulation of caldesmon's activity PMID:20858431
unphosphorylated, but not ERK-phosphorylated, caldesmon could stabilize actin filaments and resist F-actin severing or depolymerization in both smooth muscle and nonmuscle cells PMID:15456752
steady state actomyosin ATPase by caldesmon and tropomyosin PMID:16540476
interstrand crosslinking by the C-terminal actin-binding fragment of caldesmon, H32K, increases persistence length by 1.6-fold for actin filament PMID:18000881

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Subcellular Location

Cytoplasm, cytoskeleton. Cytoplasm, myofibril. Cytoplasm, cytoskeleton, stress fiber.

Protein Families

Caldesmon family

Tissue Specificity

High-molecular-weight caldesmon (h-caldesmon) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (l-caldesmon) is widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.

Database Links

UNIGENE: Gga.4988

KEGG: gga:373965

STRING: 9031.ENSGALP00000021314

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