Home
Product
Protein
Recombinant Proteins
Recombinant Chicken Calcium-activated potassium channel subunit alpha-1 (KCNMA1), partial

Recombinant Chicken Calcium-activated potassium channel subunit alpha-1 (KCNMA1), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Abbreviation

KCNMA1

Purity

>85% (SDS-PAGE)

Target Names

KCNMA1

Uniprot NO.

Q8AYS8

Alternative Names

KCNMA1; KCNMACalcium-activated potassium channel subunit alpha-1; BK channel; BKCA alpha; Calcium-activated potassium channel; subfamily M subunit alpha-1; K(VCA)alpha; KCa1.1; Maxi K channel; MaxiK; Slo-alpha; Slo1; Slowpoke homolog; Slo homolog; cSlo

Species

Gallus gallus (Chicken)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).

Gene References into Functions

findings suggest that palmitoylation of the STREX domain is necessary for cerebrosides to activate the BKCa channel PMID:24946143
These studies identify for the first time a central role for beta-catenin in mediating Slo surface expression. PMID:22194818
This comparative systems approach suggests conservation in BK function across different species in addition to novel functions that may include the initiation of signals relevant to cell death/survival. PMID:22174833
Currents from the alpha (Slo)-subunit of hair- cell BK channel alone do not show dramatic increases in response to changes in divalent calcium ion (Ca2+) concentrations at -50 millivolts expressed in low-frequency hair cells. PMID:21178105
These results indicate that delays in protein synthesis and trafficking/scaffolding of channel subunits underlie the late acquisition of BK currents in cochlear hair cells. PMID:20503427
The present results suggest that axial stretch activates BK(Ca) channels via a stretch-induced increase in the cytosolic Na(+) concentration followed by an increased Ca(2+) influx. PMID:20176677
By analyzing the complete sequences of cSlo cDNAs from the cochlea, we show that most transcripts lack alternative exons. Transcripts with more than one alternative exon constitute only 10% of the total. PMID:20479127
MAGI-1 interacts with Slo1 channel proteins and suppresses Slo1 expression on the cell surface. PMID:19403801
Tamoxifen inhibits BK channels in chick cochlea without alterations in voltage-dependent activation. PMID:19439526
These results suggest that SAK(CA) senses membrane tension through an interaction between STREX and submembranous components. PMID:19482008