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Recombinant Chicken Brain-derived neurotrophic factor (BDNF)

Recombinant Chicken Brain-derived neurotrophic factor (BDNF)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

BDNF

Uniprot NO.

P25429

Alternative Names

BDNFBrain-derived neurotrophic factor; BDNF

Species

Gallus gallus (Chicken)

Source

Yeast

Expression Region

128-246

Target Protein Sequence

HSD PARRGELSVC DSTSEWVTAA EKKTAVDMSG ATVTVLEKVP VPKGQLKQYF YETKCNPKGY TKEGCRGIDK RHWNSQCRTT QSYVRALTMD NKKRVGWRFI RIDTSCVCTL TIKRGR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Important signaling molecule that activates signaling cascades downstream of NTRK2. During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.

Gene References into Functions

The stress resilient Production Reds showed stable BDNF levels across the isolation test period whereas the vulnerable Black Australorps showed an increase in hippocampal BDNF levels PMID:23396147
Muscle cells produce and secrete proBDNF, which through its interaction with p75NTR and sortilin promotes a caspase-dependent death of motor neurons in culture. PMID:21834083
Levels of NGF, BDNF and NT-3 were all up regulated from E7 to E14 in the spinal cord of embryonic chicken during development. PMID:19764571
Blockade of spontaneous retinal activity with tetrodotoxin, or the blockade of axonal transport with colchicine, both reversed the normal mismatch between retinal BDNF mRNA and protein. PMID:15080885
BDNF expression is critically involved in thermal-experience-dependent development. PMID:16611805
These data suggest that complex and dynamic changes in DNA methylation are involved in the regulation of Bdnf expression during thermotolerance acquisition. PMID:19046370
Interactions between BDNF and the T(3) thyroid hormone and/or corticosterone may constitute a homeostatic mechanism that links hypothalamic energy regulation controlling body composition. PMID:19158410
mRNA expression level of cBDNF1 may be related to the DNA methylation status with a potential role of variant cBDNF1 in Marek disease tumor resistance and susceptibility PMID:19269281
An increase in BDNF was observed in both auditory stimulated groups. The increased levels of BDNF may help in regulating synaptic plasticity. PMID:19559781