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Recombinant Chicken B-cell linker protein (BLNK), partial

Recombinant Chicken B-cell linker protein (BLNK), partial

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MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

BLNK

Purity

>85% (SDS-PAGE)

Target Names

BLNK

Uniprot NO.

Q9YGC1

Species

Gallus gallus (Chicken)

Source

Yeast

Expression Region

1-552

Target Protein Sequence

MDKLNKLAVP AGEKFRKLQK MVHDIKKNES GIINKFKKFQ NEQVALICKT GKDTWDRLKK KPPPSLPRRD YASEHADNEE EQWSDDFDSD YENPDGHSDS EMYVVPSEEN PDDSYEPPPS EQEKKKIPSS FPISRGEYAD NRTSHHQLPP INKPLPSTPS SALPRPKKPS LPSPAAKPKL PLKPRECSDD EDNYIVPVDN DDDNYIEPTE SSTPPPAKPP VNRFMKPPAK SALPTPPKPS LASDMQEVYE VPEEEEELSP PPVTRFTKPL PATRAQNAEH SHMHSMTRES PKLDASRNIL PLPRNRLHPK TDHEANNNDE NHSFSNTQES KFPPGAAPSP LPRALKKTSN AVNPAKPCLP SRDTFTVNED KPTAADRRRG SSHEFPLPPL PSGTPKSSLQ KPLVLPKVPE APSRALGTSP HSSISSISST ADQDAGVHSK AWYAATCDRK TAEDALYRSN KDGSFLIRKS SGQDSRQPYT LVVFYNRRVY NIPIRFIEST RQYALGREKC GEERFDSVAE IVENHQHTSL VLIDSQNNTK DSTKLKYIVR VS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. Plays a critical role in B-cell development in the bursa. Plays an important role in BCR-induced apoptosis.

Gene References into Functions

In hydrogen peroxide-stimulated DT40 cells, BLNK is phosphorylated by Syk and not by Btk. PMID:11434777
Microarray analysis of SCA-2 induced bursal cells showed BLNK to be among the under-expressed genes and this was validated with qRT-PCR. PMID:19945479
short SLP-65 isoform promotes BCR-induced B-cell apoptosis PMID:16912232
BLNK recruits active H-Ras to the BCR complex, which is essential for sustained surface expression of BCR in the form of the cap and for the signal leading to functional ERK activation PMID:19218240

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Subcellular Location

Cytoplasm. Cell membrane. Note=BCR activation results in the translocation to membrane fraction.

Tissue Specificity

Highly expressed in the bursa, very low expression in ovary and spleen. Expression was variable among B-cell lines. Highly expressed in immature B-cell lines such as DT40 and CL18, low expression was seen in relatively mature B-cell lines, such as 293B9 a

Database Links

UNIGENE: Gga.3738

KEGG: gga:395733

STRING: 9031.ENSGALP00000011282

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