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Recombinant Chicken Activin receptor type-2A (ACVR2A), partial

Recombinant Chicken Activin receptor type-2A (ACVR2A), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

ACVR2A

Purity

>85% (SDS-PAGE)

Target Names

ACVR2A

Uniprot NO.

Q90669

Alternative Names

ACVR2AActivin receptor type-2A; EC 2.7.11.30; Activin receptor type IIA; ACTR-IIA; ACTRIIA

Species

Gallus gallus (Chicken)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development.

Gene References into Functions

Between broiler and layer lines, there were no significant changes in expression of the ACVR2A gene during embryonic stages but it varied significantly during the post-hatch period. The shRNA showed silencing of the ACVR2A gene under an in vitro cell culture system. PMID:27635666
Chicken ACVR2A & ACVR2B cause formation of ectopic axial structures in amphibian embryos. Authors conclude that ACVR2 receptors affect axial patterning (GO:0009798 axis specification) PMID:7589799

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily

Tissue Specificity

Expressed in hen anterior pituitary during the ovulatory cycle and in the ovarian follicle.

Database Links

UNIGENE: Gga.2852

KEGG: gga:396324

STRING: 9031.ENSGALP00000020317

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