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Recombinant Chicken Activin receptor type-1 (ACVR1), partial

Recombinant Chicken Activin receptor type-1 (ACVR1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

ACVR1

Purity

>85% (SDS-PAGE)

Target Names

ACVR1

Uniprot NO.

Q90ZK6

Alternative Names

ACVR1Activin receptor type-1; EC 2.7.11.30; Activin receptor type I; Type I TGF B receptor

Species

Gallus gallus (Chicken)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin.

Gene References into Functions

Overexpression of ACVR1Q207D-c.a. caused severe skeletal malformations in >90% of injected embryos with large ectopic cartilage condensations in all major limb joints. PMID:24852373
ALK2 was expressed in isolated chick osteoblasts and chondrocytes and specifically mediated BMP signaling. PMID:12968668
data suggest that activin receptor-like kinase (ALK) 2 activation may stimulate epithelial-mesenchymal transformation (EMT) in the atrioventricular cushion and that Smad6 may act downstream of ALK2 to negatively regulate EMT PMID:15766759
Taken together with previous in vitro studies, our results suggest that activin is a powerful regulator of neuronal differentiation in the central nervous system. PMID:16872597