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Recombinant Cat Transferrin receptor protein 1 (TFRC), partial

Recombinant Cat Transferrin receptor protein 1 (TFRC), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

TFRC

Purity

>85% (SDS-PAGE)

Target Names

TFRC

Uniprot NO.

Q9MYZ3

Alternative Names

TFRC; Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; CD antigen CD71

Species

Felis catus (Cat) (Felis silvestris catus)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Positively regulates T and B cell proliferation through iron uptake. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway. When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion. When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2.

Gene References into Functions

Mutations of several sites in the apical domain of the receptor either prevented binding to the capsids of canine parvovirus and feline panleukopenia virus or reduced the affinity of receptor binding to various degrees. PMID:20200243
TfR is the cellular receptor for Mink enteritis virus, but not the cellular receptor for Aleutian mink disease parvovirus . PMID:16040076
strong binding of feline TfR by FPV, CPV-2 capsids was seen, while CPV-2b capsids bound only weakly. PMID:16912298
Transferrin receptor, the cellular receptor for canine parvovirus, can bind to only one or a few of 60 icosahedrally equivalent sites on the virion, indicating that either canine parvovirus has inherent asymmetry or binding of receptor induces asymmetry. PMID:17420467
comparison of the abilities of TfR1 orthologs from different species to support arenavirus entry found that the human and feline receptors were able to enhance entry of the pathogenic strains, but that neither the murine or canine forms were functional. PMID:18003730