Recombinant Cat Proto-oncogene c-Fos (FOS)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

FOS

Purity

>85% (SDS-PAGE)

Target Names

FOS

Uniprot NO.

Q8HZP6

Alternative Names

FOS; Proto-oncogene c-Fos; Cellular oncogene fos

Species

Felis catus (Cat) (Felis silvestris catus)

Source

Yeast

Expression Region

1-381

Target Protein Sequence

MMFSGFNADY EASSSRCSSA SPAGDNLSYY HSPADSFSSM GSPVNAQDFC TDLAVSSANF IPTVTAISTS PDLQWLVQPT LVSSVAPSQT RAPHPYGVPA PSAGAYSRAG VVKTVTAGGR AQSIGRRGKV EQLSPEEEEK RRIRRERNKM AAAKCRNRRR ELTDTLQAET DQLEDEKSAL QTEIANLLKE KEKLEFILAA HRPACKIPDD LGFPEEMSVA SLDLSGGLPE AATPESEEAF TLPLLNDPEP KPSVEPVKSI SSMELKAEPF DDFLFPASSR PSGSETARSV PDMDLSGSFY AADWEPLHGG SLGMGPMATE LEPLCTPVVT CTPSCTTYTS SFVFTYPEAD SFPSCGAAHR KGSSSNEPSS DSLSSPTLLA L
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.

Gene References into Functions

c-Fos-positive cells in the left spinal nucleus of the trigeminus, the bilateral insula, and the bilateral operculum increased. PMID:24965534
Expression of the immediate early gene c-Fos as a marker for neurons activated by stimulation of the otoliths or the semicircular canals engages brainstem structures both within and outside of the vestibular nuclear complex (VNC). PMID:20570661
In the retina injury, the intracellular down-regulation of Fos rather than a decline in the number of Fos-immunoreactive nuclei. Interestingly, the infragranular layers displayed more Fos-immunoreactive neurons in experimental animals. PMID:20602093
C-fos protein labeled cells in laminae VII, VIII, and X are premotor interneurons involved in the production of locomotion, whereas the laminae III and IV cells are those activated during locomotion due to afferent feedback from the moving limb PMID:15634712
The presence of c-jun and c-fos proteins in neurons and glial cells of normal cats indicates that they have ongoing physiological functions in the dorsal root ganglion and spinal cord. PMID:16730915