Recombinant Cat Endothelin-1 (EDN1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

EDN1

Purity

>85% (SDS-PAGE)

Target Names

EDN1

Uniprot NO.

Q5NRQ1

Alternative Names

EDN1Endothelin-1; ET-1; Preproendothelin-1; PPET1) [Cleaved into: Big endothelin-1]

Species

Felis catus (Cat) (Felis silvestris catus)

Source

Yeast

Expression Region

53-73

Target Protein Sequence

CSCSSLLD KECVYFCHLD IIW
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Cytoplasmic domain

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells.

Gene References into Functions

we propose that endogenous ET-1 mediates the hypertrophic response to Ang II by a mechanism that involves EGFR transactivation and redox-dependent activation...in adult cardiomyocytes PMID:24327206
IT was concluded that ET-1 may prove a useful diagnostic biomarker for asthma. PMID:23750948
Positive inotropic effect after exposure to 1 nmol/L Ang II is due to endogenous ET-1 acting through ETA receptor and triggering ROS production, Na+/H+ exchanger stimulation, and Na+/Ca2+ exchanger reverse mode activation. PMID:16505203
our data suggest that ET-1 causes p38 MAPK-dependent expression of COX-2 by interacting with ETB receptors on esophageal smooth muscle cells. PMID:16951549