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Recombinant Bovine Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD)

Recombinant Bovine Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

TRADD

Purity

>85% (SDS-PAGE)

Target Names

TRADD

Uniprot NO.

Q2KI74

Alternative Names

TRADD; Tumor necrosis factor receptor type 1-associated DEATH domain protein; TNFR1-associated DEATH domain protein; TNFRSF1A-associated via death domain

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

1-312

Target Protein Sequence

MAAGPNGLEE WVGSAYLFVE SSLDKVVLSD AYAHQQQKVA MYGALQTALA ESGGSPDVLQ MLKIHRSDPQ LIVQLRFSGR QACSRFLRAY REGALRATLQ GCLARALALN SVPLQLELRA GAEQLDALLT NEERCLNCIC AQKPDRLRDE ELTELENALR NLTCGSAGGQ GSDVQGTPAP LQSLAPSPPE EKPPPPQPGQ TFLFQGQPIV NRPLNLQDQQ KFARSVGLKW RKVGRSLQRS CRALRDPALD SLAYEYERDG LYEQAFQLLR RFVQAEGRRA TLQRLVEALE ENELTSLAED LLGLANPDGS LA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function(From Uniprot)

Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A.

Gene References into Functions

TNF binding induces release of AIP1 (DAB2IP) from TNFR1, resulting in cytoplasmic translocation and concomitant formation of an intracellular signaling complex comprised of TRADD, RIP1, TRAF2, and AIPl. PMID:15310755

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Subcellular Location

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton.

Database Links

UNIGENE: Bt.15875

KEGG: bta:504707

STRING: 9913.ENSBTAP00000016776

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