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Recombinant Bovine Tissue-type plasminogen activator (PLAT), partial

Recombinant Bovine Tissue-type plasminogen activator (PLAT), partial

Code
MSDS	MSDS
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

PLAT

Uniprot NO.

Q28198

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

37-566

Target Protein Sequence

SYKV TCRDGKTQMT YRQHDSWLRP LLRGNQVEHC WCDGGRAQCH SVPVRSCSEP WCFNGGTCRQ ALYSSDFVCQ CPEGFMGKLC EIDATATCYK DQGVAYRGTW STAESGAECA NWNSSGLAMK PYSGRRPNAI RLGLGNHNYC RNPDQDSKPW CYVFKAGKYI SEFCSTPACA KVAEEDGDCY TGNGLAYRGT RSHTKSGASC LPWNSVFLTS KIYTAWKSNA PALGLGKHNH CRNPDGDAQP WCHVWKDRQL TWEYCDVPQC VTCGLRQYKR PQFRIKGGLF ADITSHPWQA AIFVKNRRSP GERFLCGGIL ISSCWVLSAA HCFQERYPPH HLKVFLGRTY RLVPGEEEQT FEVEKYIIHK EFDDDTYDND IALLHLKSDS LTCARESASV RTICLPDASL QLPDWTECEL SGYGKHESSS PFFSERLKEA HVRLYPSSRC TSQHLFNRTV TNNMLCAGDT RSGGDHTNLH DACQGDSGGP LVCMKDNHMT LVGIISWGLG CGRKDVPGVY TKVTNYLDWI RDNTRP

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

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Target Background

Function

Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy.

Gene References into Functions

The plasminogen/plasminogen activator/plasmin system is activated during gamete interaction and regulates the sperm entry into the oocyte. PMID:22177313
stage-dependent regulation of granulosa cell PA and SerpinE2 production, consistent with a role in extracellular matrix remodeling during follicle growth PMID:15128599
These results suggest that Neovastat induces tPA gene transcription through activation of the JNK and NFkappaB signaling pathways, leading to an increase of tPA secretion by endothelial cells. PMID:15207722

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Subcellular Location

Secreted, extracellular space.

Protein Families

Peptidase S1 family

Database Links

UNIGENE: Bt.12302

KEGG: bta:281407

STRING: 9913.ENSBTAP00000001642

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