Recombinant Bovine Thyroglobulin (TG), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Uniprot NO.

P01267

Alternative Names

TG; Thyroglobulin; Tg

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

20-2769

Target Protein Sequence

N IFEYQVDAQP LRPCELQRER AFLKREDYVP QCAEDGSFQT VQCGKDGASC WCVDADGREV PGSRQPGRPA ACLSFCQLQK QQILLSSYIN STATSYLPQC QDSGDYSPVQ CDLRRRQCWC VDAEGMEVYG TRQQGRPARC PRSCEIRNRR LLHGVGDRSP PQCSPDGAFR PVQCKLVNTT DMMIFDLVHS YSRFPDAFVT FSSFRSRFPE VSGYCYCADS QGRELAETGL ELLLDEIYDT IFAGLDLAST FAETTLYRIL QRRFLAVQLV ISGRFRCPTK CEVERFAATS FRHPYVPSCH PDGEYQAAQC QQGGPCWCVD SRGQEIPGTR QRGEPPSCAE DQSCPSERRR AFSRLRFGPS GYFSRRSLLL APEEGPVSQR FARFTASCPP SIKELFLDSG IFQPMLQGRD TRFVAPESLK EAIRGLFPSR ELARLALQFT TNAKRLQQNL FGGRFLVKVG QFNLSGALGT RGTFNFSHFF QQLGLPGFQD GRALADLAKP LSVGLNSNPA SEAPKASKID VALRKPVVGS FGFEVNLQEN QNALQFLSSF LELPEFLLFL QHAISVPEDI ARDLGDVMEM VFSSQGCGQA PGSLFVPACT AEGSYEEVQC FAGDCWCVDA QGRELAGSRV RGGRPRCPTE CEKQRARMQS LLGSQPAGSS LFVPACTSKG NFLPVQCFNS ECYCVDTEGQ PIPGTRSALG EPKKCPSPCQ LQAERAFLGT VRTLVSNPST LPALSSIYIP QCSASGQWSP VQCDGPPEQA FEWYERWEAQ NSAGQALTPA ELLMKIMSYR EAASRNFRLF IQNLYEAGQQ GIFPGLARYS SFQDVPVSVL EGNQTQPGGN VFLEPYLFWQ ILNGQLDRYP GPYSDFSAPL AHFDLRSCWC VDEAGQKLEG TRNEPNKVPA CPGSCEEVKL RVLQFIREAE EIVTYSNSSR FPLGESFLAA KGIRLTDEEL AFPPLSPSRE TFLEKFLSGS DYAIRLAAQS TFDFYQRRLV TLAESPRAPS PVWSSAYLPQ CDAFGGWEPV QCHAATGHCW CVDGKGEYVP TSLTARSRQI PQCPTSCERL RASGLLSSWK QAGVQAEPSP KDLFIPTCLE TGEFARLQAS EAGTWCVDPA SGEGVPPGTN SSAQCPSLCE VLQSGVPSRR TSPGYSPACR AEDGGFSPVQ CDPAQGSCWC VLGSGEEVPG TRVAGSQPAC ESPQCPLPFS VADVAGGAIL CERASGLGAA AGQRCQLRCS QGYRSAFPPE PLLCSVQRRR WESRPPQPRA CQRPQFWQTL QTQAQFQLLL PLGKVCSADY SGLLLAFQVF LLDELTARGF CQIQVKTAGT PVSIPVCDDS SVKVECLSRE RLGVNITWKL QLVDAPPASL PDLQDVEEAL AGKYLAGRFA DLIQSGTFQL HLDSKTFSAD TSIRFLQGDR FGTSPRTQFG CLEGFGRVVA ASDASQDALG CVKCPEGSYF QDEQCIPCPA GFYQEQAGSL ACVPCPEGRT TVYAGAFSQT HCVTDCQKNE VGLQCDQDSQ YRASQRDRTS GKAFCVDGEG RRLPWTEAEA PLVDAQCLVM RKFEKLPESK VIFSADVAVM VRSEVPGSES SLMQCLADCA LDEACGFLTV STAGSEVSCD FYAWASDSIA CTTSGRSEDA LGTSQATSFG SLQCQVKVRS REGDPLAVYL KKGQEFTITG QKRFEQTGFQ SALSGMYSPV TFSASGASLA EVHLFCLLAC DHDSCCDGFI LVQVQGGPLL CGLLSSPDVL LCHVRDWRDP AEAQANASCP GVTYDQDSRQ VTLRLGGQEI RGLTPLEGTQ DTLTSFQQVY LWKDSDMGSR SESMGCRRDT EPRPASPSET DLTTGLFSPV DLIQVIVDGN VSLPSQQHWL FKHLFSLQQA NLWCLSRCAG EPSFCQLAEV TDSEPLYFTC TLYPEAQVCD DILESSPKGC RLILPRRPSA LYRKKVVLQD RVKNFYNRLP FQKLTGISIR NKVPMSDKSI SSGFFECERL CDMDPCCTGF GFLNVSQLKG GEVTCLTLNS LGLQTCSEEY GGVWRILDCG SPDTEVRTYP FGWYQKPVSP SDAPSFCPSV ALPALTENVA LDSWQSLALS SVIVDPSIRN FDVAHISTAA VGNFSAARDR CLWECSRHQD CLVTTLQTQP GAVRCMFYAD TQSCTHSLQA QNCRLLLHEE ATYIYRKPNI PLPGFGTSSP SVPIATHGQL LGRSQAIQVG TSWKPVDQFL GVPYAAPPLG EKRFRAPEHL NWTGSWEATK PRARCWQPGI RTPTPPGVSE DCLYLNVFVP QNMAPNASVL VFFHNAAEGK GSGDRPAVDG SFLAAVGNLI VVTASYRTGI FGFLSSGSSE LSGNWGLLDQ VVALTWVQTH IQAFGGDPRR VTLAADRGGA DIASIHLVTT RAANSRLFRR AVLMGGSALS PAAVIRPERA RQQAAALAKE VGCPSSSVQE MVSCLRQEPA RILNDAQTKL LAVSGPFHYW GPVVDGQYLR ETPARVLQRA PRVKVDLLIG SSQDDGLINR AKAVKQFEES QGRTSSKTAF YQALQNSLGG EAADAGVQAA ATWYYSLEHD SDDYASFSRA LEQATRDYFI ICPVIDMASH WARTVRGNVF MYHAPESYSH SSLELLTDVL YAFGLPFYPA YEGQFTLEEK SLSLKIMQYF SNFIRSGNPN YPHEFSRRAP EFAAPWPDFV PRDGAESYKE LSVLLPNRQG LKKADCSFWS KYIQSLKASA DETKDGPSAD SEEEDQPAGS GLTEDLLGLP ELASKTYSK
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling. Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream. One dimer produces 7 thyroid hormone molecules.

Gene References into Functions

Data suggest that flotillin-1 and flotillin-2 function as thyroglobulin-binding proteins in lipid rafts of thyrocytes; these interactions appear to exert negative-feedback effects on gene expression in thyrocytes. PMID:27676653
There were no associations between x genotype and fertility related traits in this study. PMID:27065254
The results of this study suggest that TG gene-specific SNPs may be a useful marker for growth traits in marker-assisted selection programs in beef cattle. PMID:26125728
Solution studies, size exclusion chromatography, dynamic light scattering and analytical ultracentrifugation, demonstrated the size changes of thyroglobulin oligomers after nitric oxide treatment. PMID:24264462
The genetic effects of thyroglobulin and casein alpha s1 alpha in the body fat distribution of cattle are reported. PMID:23148258
TG gene-specific single nucleotide polymorphism may be a useful marker for meat quality traits. PMID:21153925
The results confirm the lack of an association found by many other studies and suggest that these SNPs are not influential on the divergent intramuscular fat levels in the crossbred population tested. PMID:20416823
Localization of thyrotropin receptor and thyroglobulin in the bovine corpus luteum. PMID:19553036
Atrial natriuretic peptide inhibits iodide uptake and thyroglobulin messenger ribonucleic acid expression in cultured bovine thyroid follicles. PMID:12047906
Markers at the thyroglobulin gene may be a useful predictor of marbling performance for producers raising Wagyu-based cattle; the SNP reported in the thyroglobulin gene was associated with marbling score in cattle with Wagyu inheritance PMID:17686891
Single nucleotide polymorphism of thyroglobulin gene is associated with fat deposition. PMID:18670061
we have demonstrated for the first time that thyroglobulin possesses proliferative effect on thyroid epithelial cells in addition to being the precursor of the thyroid hormones. PMID:19261995
Immunization with Tg induces Graves'-like disease in mice and that our methods will provide a new animal model of Graves' disease. PMID:19491147