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Recombinant Bovine Thimet oligopeptidase (THOP1), partial

Recombinant Bovine Thimet oligopeptidase (THOP1), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

THOP1

Purity

>85% (SDS-PAGE)

Target Names

THOP1

Uniprot NO.

Q1JPJ8

Alternative Names

THOP1; Thimet oligopeptidase; EC 3.4.24.15

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

1-687

Target Protein Sequence

MKPPAACTGD ALDVVAPCSA VNHLRWDLSA QQIAELTTEL IEQTKRVYDC VGAQEPQDVS YENTLKALAD VEVSYTVQRN ILDFPQHVSP SKDIRTASTE ADKKLSEFDV EMSMRQDVYQ RIVWLQEKVQ KDSLRPEASR YLERLIKLGR RNGLHLPEET QEKIKSIKKK LSLLCIDFNK NLNEDTTFLP FTREELGGLP EDFLNSLEKT EDEKLKVTLK YPHYFPLLKK CHVPETRRKV EEAFNCRCKE ENCAILRELV RLRAQKSRLL GFSTHADYVL EMNMAKTSQV VATFLDELAQ KLKPLGEQER AVILELKRAE CEQRGLAFDG RINAWDMRYY MNQVEETRYR VDQNLLKEYF PMQVVTRGLL GIYQELLGLS FQLEEGAAVW HEDVALYAVR DAASGKLIGK FYLDLYPREG KYGHAACFGL QPGCLRKDGS RQIAIAAMVA NFTKPTPDAP SLLQHDEVET YFHEFGHVMH QLCSQAEFAM FSGTHVERDF VEAPSQMLEN WVWEAEPLLR MSQHYRTGSS IPQELLDKLI KSRQANTGLF NLRQIVLAKV DQALHTQTAA DPAKEYARLC QEILGVPATP GTNMPATFGH LAGGYDAQYY GYLWSEVYSA DMFHTRFKQE GVLSGKVGMD YRSCILRPGG SEDASVMLKL FLGRDPKQDA FLLSKGLQVE GCEPPAC
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments.

Gene References into Functions

shear-dependent TOP induction down-regulates MHC1 levels, pointing to a role for TOP in the flow-mediated regulation of endothelial immunogenicity PMID:23708739
Cyclic strain putatively regulates both the mRNA expression and enzymatic function of EP24.15 and EP24.16. PMID:14726412

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Subcellular Location

Cytoplasm.

Protein Families

Peptidase M3 family

Database Links

UNIGENE: Bt.21827

KEGG: bta:510889

STRING: 9913.ENSBTAP00000027246

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