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Recombinant Bovine Suppressor of cytokine signaling 3 (SOCS3)

Recombinant Bovine Suppressor of cytokine signaling 3 (SOCS3)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

SOCS3

Purity

>85% (SDS-PAGE)

Target Names

SOCS3

Uniprot NO.

Q9BEG9

Alternative Names

SOCS3; Suppressor of cytokine signaling 3; SOCS-3

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

1-229

Target Protein Sequence

MVTHSKFPAA GMSRPLDTSL RLKTFSSKSE YQLVVNAVRK LQESGFYWST VTGGEANLLL SAEPAGTFLI RDSSDQRHFF TLSVKTQSGT KNLRIQCEGG SFSLQSDPRS TQPVPRFDCV LKLVHHYMPA AGAPSFSQPP AEPSSSPSSE VPEQPPAQPL SGNPPRRAYY IYSGGEKIPL VLSRPLSSNV ATLQHLCRKT VNGHLDSYEK VTQLPGPIRE FLDQYDAPL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene References into Functions

Low SOCS3 expression is required for milk synthesis and proliferation of dairy cow mammary epithelial cells in vitro. PMID:24141248
Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 and SOCS-3, which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses. PMID:16111147

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Database Links

UNIGENE: Bt.8137

KEGG: bta:282081

STRING: 9913.ENSBTAP00000011106

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