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Recombinant Bovine Poly (ADP-ribose) glycohydrolase (PARG), partial

Recombinant Bovine Poly (ADP-ribose) glycohydrolase (PARG), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

PARG

Uniprot NO.

O02776

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

1-977

Target Protein Sequence

MSAGPGCEPC TKRPRWDAAA TSPPAASDAR SFPGRQRRVL DSKDAPVQFR VPPSSSGCAL GRAGQHRGSA TSLVFKQKTI TSWMDTKGIK TVESESLHSK ENNNTREESM MSSVQKDNFY QHNMEKLENV SQLGFDKSPV EKGTQYLKQH QTAAMCKWQN EGPHSERLLE SEPPAVTLVP EQFSNANVDQ SSPKDDHSDT NSEESRDNQQ FLTHVKLANA KQTMEDEQGR EARSHQKCGK ACHPAEACAG CQQEETDVVS ESPLSDTGSE DVGTGLKNAN RLNRQESSLG NSPPFEKESE PESPMDVDNS KNSCQDSEAD EETSPGFDEQ EDSSSAQTAN KPSRFQPREA DTELRKRSSA KGGEIRLHFQ FEGGESRAGM NDVNAKRPGS TSSLNVECRN SKQHGRKDSK ITDHFMRVPK AEDKRKEQCE MKHQRTERKI PKYIPPHLSP DKKWLGTPIE EMRRMPRCGI RLPPLRPSAN HTVTIRVDLL RIGEVPKPFP THFKDLWDNK HVKMPCSEQN LYPVEDENGE RAAGSRWELI QTALLNRLTR PQNLKDAILK YNVAYSKKWD FTALIDFWDK VLEEAEAQHL YQSILPDMVK IALCLPNICT QPIPLLKQKM NHSITMSQEQ IASLLANAFF CTFPRRNAKM KSEYSSYPDI NFNRLFEGRS SRKPEKLKTL FCYFRRVTEK KPTGLVTFTR QSLEDFPEWE RCEKLLTRLH VTYEGTIEGN GQGMLQVDFA NRFVGGGVTS AGLVQEEIRF LINPELIVSR LFTEVLDHNE CLIITGTEQY SEYTGYAETY RWARSHEDRS ERDDWQRRTT EIVAIDALHF RRYLDQFVPE KIRRELNKAY CGFLRPGVSS ENLSAVATGN WGCGAFGGDA RLKALIQILA AAVAERDVVY FTFGDSELMR DIYSMHTFLT ERKLTVGEVY KLLLRYYNEE CRNCSTPGPD IKLYPFIYHA VESCTQTTNQ PGQRTGA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Poly(ADP-ribose) glycohydrolase that degrades poly(ADP-ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP-ribose). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers. It is however unable to cleave the ester bond between the terminal ADP-ribose and ADP-ribosylated residues, leaving proteins that are mono-ADP-ribosylated. Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG. Required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress, while it is not required for recovery from transient replicative stress. Responsible for the prevalence of mono-ADP-ribosylated proteins in cells, thanks to its ability to degrade poly(ADP-ribose) without cleaving the terminal protein-ribose bond. Required for retinoid acid-dependent gene transactivation, probably by removing poly(ADP-ribose) from histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters. Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming.

Subcellular Location

Nucleus.

Protein Families

Poly(ADP-ribose) glycohydrolase family

Database Links

UNIGENE: Bt.106829

KEGG: bta:281377

STRING: 9913.ENSBTAP00000031225

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