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Recombinant Bovine Pigment epithelium-derived factor (SERPINF1)

Recombinant Bovine Pigment epithelium-derived factor (SERPINF1)

Baculovirus
Mammalian cell

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

SERPINF1

Purity

>85% (SDS-PAGE)

Target Names

SERPINF1

Uniprot NO.

Q95121

Alternative Names

SERPINF1; PEDFPigment epithelium-derived factor; PEDF; Serpin F1

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

21-416

Target Protein Sequence

NAGQEAGSLT PESTGAPVEE EDPFFKVPVN KLAAAVSNFG YDLYRVRSGE SPTANVLLSP LSVATALSAL SLGAEQRTES NIHRALYYDL ISNPDIHGTY KDLLASVTAP QKNLKSASRI IFERKLRIKA SFIPPLEKSY GTRPRILTGN SRVDLQEINN WVQAQMKGKV ARSTREMPSE ISIFLLGVAY FKGQWVTKFD SRKTSLEDFY LDEERTVKVP MMSDPQAVLR YGLDSDLNCK IAQLPLTGST SIIFFLPQKV TQNLTLIEES LTSEFIHDID RELKTVQAVL TIPKLKLSYE GELTKSVQEL KLQSLFDAPD FSKITGKPIK LTQVEHRVGF EWNEDGAGTN SSPGVQPARL TFPLDYHLNQ PFIFVLRDTD TGALLFIGKI LDPRGT
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function(From Uniprot)

Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

Gene References into Functions

PEDF inhibits key steps in the angiogenic response of retinal capillary endothelial cells, including cell proliferation and vascular tubule formation. Gene expression of PEDF is negatively regulated by glucose, insulin (via mTOR) and VEGF. PMID:20219495
Results suggest that leptin might elicit angiogenesis through vascular endothelial growth factor induction as well as pigment epithelium-derived factor suppression in pericytes. PMID:12779248
PEDF promotes growth of pericytes through autocrine production of PDGFB. PMID:15896354
PEDF and VEGFR-1 have roles in the negative regulation of angiogenesis PMID:16339148

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Subcellular Location

Secreted. Melanosome.

Protein Families

Serpin family

Tissue Specificity

Retinal pigment epithelial cells. Located in the interphotoreceptor matrix (IPM) which is between the retinal pigment epithelium and the neural retina.

Database Links

UNIGENE: Bt.2638

KEGG: bta:281386

STRING: 9913.ENSBTAP00000012804

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