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Recombinant Bovine Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A), partial

Recombinant Bovine Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

PPARGC1A

Purity

>85% (SDS-PAGE)

Target Names

PPARGC1A

Uniprot NO.

Q865B7

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

1-796

Target Protein Sequence

MAWDMCNQDS VWSDIECAAL VGEDQPLCPD LPELDLSELD VNDLDTDSFL GGLKWCSDQS EIISNQYNNE PSNIFEKIDE ENEANLLAVL TETLDSLPVD EDGLPSFDAL TDGDVTTENE ASPSSMPDGT PPPQEAEEPS LLKKLLLAPA NTQLSYNECS GLSTQNHANH NHRIRTNPAV VKTENSWSNK AKSICQQQKP QRRPCSELLK YLTTNDDPPH TKPTENRNSS RDKCTSKKKA HTQSQTQHLQ AKPTTLSLPL TPESPNDPKG SPFENKTIER TLSVELSGTA GLTPPTTPPH KANQDNPFRA SPKLKPSCKT VVPPPSKKAR YSESSCTQGS NSTKKGPEQS ELYAQLSKTS VLTSGHEERK AKRPSLRLFG DHDYCQSINS KTEILVSTSQ ELHDSRQLEN KDAPSSNGPG QIHSSTDSDP CYLRETAEVS RQVSPGSTRK QLQDQEIRAE LNKHFGHPSQ AVFDDKADKT SELRDSDFSN EQFSKLPMFI NSGLAMDGLF DDSEDESDKL NSPWDGTQSY SLFDVSPSCS SFNSPCRDSV SPPKSLFSQR PQRMRSRSRS FSRHRSCSRS PYSRSRSRSP GSRSSSRSCY YYESGHCRHR THRNSPLCAS RSRSPHSRRP RYDSYEEYQH ERLKREEYRR EYEKRESERA KQRERQRQKA IEERRVIYVG KIRPDTTRTE LRDRFEVFGE IEECTVNLRD DGDSYGFITY RYTCDAFAAL ENGYTLRRSN ETDFELYFCG RKQFFKSNYA DLDSNSDDFD PACIKSKYDS LDFDSLLKEA QRSLRR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.

Gene References into Functions

PPARGC1A single nucleotide polymorphisms associated with milk fatty acids in a Chinese Holstein cattle. PMID:27468856
regulatory role in intramuscular fat deposition PMID:24778332
The PPARGC1A synonymous mutation c.396G>A significantly associated with body weight and average daily gain in Nanyang cattle at the adult age. PMID:24197695
PPARGC1A genotypes had a significant effect on lengths of calving interval and calving to conception interval, and the T allele was demonstrated to have an unfavourable effect on these traits. PMID:23342912
NO/protein kinase G (PKG)-dependent downregulation of PGC-1 alpha and the ROS detoxification system in endothelial cells are mediated by the PI3K/Akt signaling PMID:20547753
The effects of dietary fat components on the expression of PPAR-gamma AND PPAR-gamma coactivator 1 in cultured bovine preadipocytes are reported. PMID:20154154
Data show that two SNPs (Single Nucleotide Polymorphisms) were identified within exon 8 by multiple alignment of DNA sequences obtained from 24 bulls: a transition G/A (SNP 1181) and a transversion A/T (SNP 1299). PMID:19665052
genetic analysis of bovine PPARGC1A PMID:15781588
PPARGC1A was associated with a significant increase in milk protein percentage in contrast to association results previously reported for the German Holstein population PMID:17517737