Recombinant Bovine Oxytocin-neurophysin 1 (OXT)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

OXT

Uniprot NO.

P01175

Alternative Names

OXT; Oxytocin-neurophysin 1; OT-NPI) [Cleaved into: Oxytocin; Ocytocin); Neurophysin 1]

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

32-125

Target Protein Sequence

AVLDLDVRT CLPCGPGGKG RCFGPSICCG DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSGGRCAA AGICCSPDGC HEDPACDPEA AFSQH
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Neurophysin 1 specifically binds oxytocin.; Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR).

Gene References into Functions

Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1/oxytocin system. PMID:28163019
Oxytocin (OT) mRNA and protein levels were lower in the corpus luteum of pregnancy than in the corpus luteum of the estrous cycle. PMID:24856470
These data suggest that cortisol affects oxytocin synthesis and secretion in bovine ovarian cells, by acting on the expression of key genes, that may impair ovary PMID:23971190
Binding of oestrogen receptor-related receptor alpha to the oxytocin promoter binding site is demonstrated, suggesting the involvement of this receptor in oestrogen-dependent up-regulation. PMID:15842231
data demonstrate an effect of dimerization in the unliganded state on the hormone-binding site involving residues that interact with hormone residue 2, & identify Ser25 & Ile26 as likely intermediaries between the sites of dimerization & hormone binding PMID:16128578
loop status modulates dimerization via long-range effects on neurophysin conformation involving neighboring Phe22 as a key intermediary PMID:17192588
Intraluteal OXT may locally modulate secretion of vasoactive substances, particularly EDN1 and PGF(2alpha) within the corpus luteum. PMID:17287495