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Recombinant Bovine Nucleotide-binding oligomerization domain-containing protein 2 (NOD2), partial

Recombinant Bovine Nucleotide-binding oligomerization domain-containing protein 2 (NOD2), partial

Baculovirus
Mammalian cell

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

NOD2

Purity

>85% (SDS-PAGE)

Target Names

NOD2

Uniprot NO.

Q6E804

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

1-1013

Target Protein Sequence

MCAQDAFQTQ RSQLVELLVS GSLEGFESIL DRLLSREVLS WEDYEGLSLV GQPISHLARR LLDTIWNKGT WGCEQLTAAV REAQADSQPP ELPSSWDPHS PHPARDLQSH RPAIVRRLYG HVEGVLDLTQ QRGFISQYET DEIRRPIFTS SQRARRLLDL ATVKANGLAA FLLQCIQELP VPLALPFEDA ACKKYVSKLR TVISAQSRFL STYDGAENLC LEEVYTENVL EIQMEVGMAG PSQQSPTTLG LEELFSTRDH FNKEADTVLV VGEAGSGKST LLQQLHLLWA SGRAFQEFLF VFPFSCRQLQ CLVKPLSMRT LLFEHCCWPD LGPQDVFQVL LDHPERILLT FDGFDEFRFR FTDQERHCCP TAPTSVQSLL FNLLQGNLLK NARKVLTSRP SAVSASLRKH VRTELSLKGF SEEGIELYLR KRHREPGVAD RLLCLLRATS ALHGLCHLPV FSWMVSKCHE ELLLQGRGSP KTTTDMYLLI LRHFLLHASP LPLATHGLGP SLIQGRLPTL LHLGRLALWG LGTCCYVFSA KQLQAAHVDS EDLSLGFLVL AKRVVPGSTA PLEFLHITFQ CFFAAFYLAL SADTPPSSLR HLFQDHRPES SPLARVLPKL FLRGSRCREG SVAALLQGAE PHNLQITGAF LAGLLSQEHR SLLAECQASE TALLRRWDCV RRCLTRSLRE HFRSIPPALP GEAKSMHALP GFLWLIRSLY EMQEERLARE AVCRLNVGHL KLTFCGVGPA ECAALAFVLR HLRRPVALQL DHNSVGDIGV EQLLPCLGVC KALYLRDNNI SDRGICKLVE HALRCEQLQK LALFNNKLTD GCAHSMARLL ACKQNFLALR LGNNHITAAG AEVLAQGLRT NNSLQFLGFW GNQVGDEGAQ ALAAALGDHQ SLRWLSLVGN NIGSVGAQAL ALMLEKNMAL EELCLEENHV QDEGVCFLAK GLARNSSLKV LKLSNNHISS LGAEALLRAL EKNDTILEVW LRGNTFSPEE IEKLSHQDTR LLL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages. Component of an autophagy-mediated antibacterial pathway together with ATG16L1. Plays also a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon.

Gene References into Functions

These results revealed that thermal stress increased the expression levels of NOD1/2 genes and acute inflammatory cytokines which sheds some light on their role on immune response of the host cells during thermal stress.These preliminary studies indicated that the immune-related genes differentially expressed during thermal stress among native and crossbred cattle. PMID:27853874
Data indicate six single-nucleotide polymorphisms (SNPs) in the caspase recruitment domain 15 protein (CARD15) gene associated with susceptibility to bovine tuberculosis (BTB) in Chinese Holstein cows. PMID:26244859
Data indicate that the Nod2 signaling adaptor protein (NOD2) G-->A at position 1594 bp plays a critical role in increasing 305-day milk yields. PMID:25966125
Genetic variation and putative regulatory regions in bovine CARD15. PMID:16897345
This study indicates that SNP c.3020A>T might play a role in the host response against mastitis and further detailed studies are needed to understand its functional mechanisms PMID:18005441
A significant association was found between two polymorphisms of CARD15 and paratuberculosis status; cows with the heterozygous genotype were 3.35 times more likely to be infected than cows with the reference genotype. PMID:18926647