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Recombinant Bovine Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7), partial

Recombinant Bovine Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

CHRNA7

Uniprot NO.

P54131

Alternative Names

CHRNA7Neuronal acetylcholine receptor subunit alpha-7

Species

Bos taurus (Bovine)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

Gene References into Functions

We conclude that residues in the M2 segment and flanking regions contribute to the unusual properties of the CHRNA7 receptor PMID:21790604
Deletion of a small cytoplasmic fragment close to the fourth transmembrane segment of the nicotinic alpha7 receptor (Glu437 to Arg447) abolished membrane expression PMID:21729697
Data show that basic residues at positions 208 and 210 are necessary for the assembly of alpha7 receptors. PMID:21420959
Cultured bovine retinal pigment epitheliumcells expressed nicotinic receptors containing alpha7 subunit PMID:20932358
Loop 9 has a different role in the function of homomeric and heteromeric receptors. PMID:20043866
Loop 3 and its docking to the alpha-helix is an important requirement for receptor assembly of the alpha7 nicotinic receptor. PMID:19840217
Bovine chromaffin cells have an alpha3alpha7beta4 nicotinic receptor PMID:12438113
a network of interactions formed by residues Lys-46, Asp-128, Asp-135, Asp-266, and possibly others appears to link agonist binding to channel gating PMID:15611071
involvement of Lys145 in the early steps of channel activation by acetylcholine PMID:16129734
slowly desensitizing mutant alpha7L248T could be an interesting tool for the study of channel activation in alpha7 receptors PMID:19063861