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Recombinant Bovine Multidrug resistance-associated protein 1 (ABCC1), partial

Recombinant Bovine Multidrug resistance-associated protein 1 (ABCC1), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

ABCC1

Purity

>85% (SDS-PAGE)

Target Names

ABCC1

Uniprot NO.

Q8HXQ5

Alternative Names

ABCC1; MRP1; Multidrug resistance-associated protein 1; EC 7.6.2.2; ATP-binding cassette sub-family C member 1; Glutathione-S-conjugate-translocating ATPase ABCC1; EC 7.6.2.3; Leukotriene C(4) transporter; LTC4 transporter

Species

Bos taurus (Bovine)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation. Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells.

Gene References into Functions

Using electron cryomicroscopy, authors determined the molecular structures of bovine MRP1 in two conformations: an apo form at 3.5 A without any added substrate and a complex form at 3.3 A with one of its physiological substrates, leukotriene C4; structures show that by forming a single bipartite binding site, MRP1 can recognize a of substrates with different chemical structures. PMID:28238471
P-gp, Bcrp and Mrp1 are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport. PMID:24934296

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily

Tissue Specificity

Expressed in heart, spleen, lung, kidney, skeletal muscle, mammary gland and weaker in brain and liver.

Database Links

UNIGENE: Bt.88646

KEGG: bta:281588

STRING: 9913.ENSBTAP00000028094

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