Recombinant Bovine Mucin-1 (MUC1), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details

Abbreviation

MUC1

Purity

>85% (SDS-PAGE)

Target Names

MUC1

Uniprot NO.

Q8WML4

Alternative Names

MUC1; Mucin-1; MUC-1; CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha; MUC1-NT; MUC1-alpha); Mucin-1 subunit beta; MUC1-beta; MUC1-CT)]

Species

Bos taurus (Bovine)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

The alpha subunit has cell adhesive properties. May provide a protective layer on epithelial cells against bacterial and enzyme attack.; The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, Src and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates P53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of P53 and represses P53 activity.

Gene References into Functions

Endometrial expressions of MUC1 and cytokine genes differed among normal, fertile versus diseased, and subfertile dairy cows. PMID:24576715
Bovine Muc1 prevents binding of bacteria to human intestinal cells and may have a role in preventing the binding of common enteropathogenic bacteria to human intestinal epithelial surfaces. PMID:19936918
concluded that bovine Muc1 protein is probably an inducible innate immune effector and an important component of the first line of defense against bacterial invasion of epithelial surfaces PMID:19762846

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Subcellular Location

Apical cell membrane; Single-pass type I membrane protein.; [Mucin-1 subunit beta]: Cell membrane. Cytoplasm. Nucleus.

Tissue Specificity

Expressed on the apical surface of epithelia cells, and on the milk fat globule membrane (MGGM).

Database Links

UNIGENE: Bt.9561

KEGG: bta:281333

STRING: 9913.ENSBTAP00000014051

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