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Recombinant Bovine Metalloproteinase inhibitor 1 (TIMP1)

Recombinant Bovine Metalloproteinase inhibitor 1 (TIMP1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

TIMP1

Uniprot NO.

P20414

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

24-207

Target Protein Sequence

CTCVPPH PQTAFCNSDV VIRAKFVGTA EVNETALYQR YEIKMTKMFK GFSALRDAPD IRFIYTPAME SVCGYFHRSQ NRSEEFLIAG QLSNGHLHIT TCSFVAPWNS MSSAQRRGFT KTYAAGCEEC TVFPCSSIPC KLQSDTHCLW TDQLLTGSDK GFQSRHLACL PREPGLCTWQ SLRAQMA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling.

Gene References into Functions

Decreased MMP-9 and increased TIMP-1 expression were found in peripheral blood cells from Mycobacterium avium subsp. paratuberculosis (Map)-infected cattle after stimulation with Map lysate and Map purified protein derivative than in control cattle. PMID:21328105
We used a trophoblast cell line (F3) derived from bovine placentomes to examine the influence of EGF on MMP-9 and TIMP-1 expression by semiquantitative RT-PCR and MMP activity by zymography. PMID:20578063
Production of TIMP-1 was augmented by IL-1alpha, TNFalpha, and hepatocyte growth factor at level of translation and was transcriptionally increased by 12-O-tetradecanoylphorbol 13-acetate. Level of TIMP-2 mRNA was not affected by any treatments. PMID:12606436
the different temporal expression patterns of TIMP-1 and TIMP-2 suggest that TIMP-1 may be important for luteal formation and development, while TIMP-2 may play significant roles during luteal development and maintenance PMID:14613539
Identification, purification and partial characterization of bovine pulmonary artery smooth muscle tissue inhibitor of matrix metalloproteinase-1 PMID:14674693
analysis of species specificity of human and bovine TIMP-1 binding to mouse TIMP-1 receptor PMID:16019435