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Recombinant Bovine Membrane cofactor protein (CD46), partial

Recombinant Bovine Membrane cofactor protein (CD46), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

CD46

Purity

>85% (SDS-PAGE)

Target Names

CD46

Uniprot NO.

Q6VE48

Species

Bos taurus (Bovine)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. In case of bovine viral diarrhea virus (BVDV) infection, involved in virus attachment to cells.

Gene References into Functions

study found that sCD46 is not detectable in fetal and neonatal sera and that its plasma concentration increases progressively up to adulthood; also detected high- and low-sCD46 performers and show that this phenotype does not depend of environmen. PMID:27865262
Study shows the existence of 10 distinct allelic versions of the CCP1 module of CD46; ectopic expression of the 10 bovine CD46 isoforms rendered the PK15 cells permissive to bovine viral diarrhea virus. PMID:21680116
localization of CD46 on bovine sperm membrane PMID:21869454

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Subcellular Location

Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein.

Tissue Specificity

Highly expressed at the blood-brain barrier. Broadly expressed, with highest levels in thymus and spleen (at protein level).

Database Links

UNIGENE: Bt.53657

KEGG: bta:280851

STRING: 9913.ENSBTAP00000007107

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