Recombinant Bovine Lactadherin (MFGE8)

Baculovirus
Mammalian cell

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

MFGE8

Purity

>85% (SDS-PAGE)

Target Names

MFGE8

Uniprot NO.

Q95114

Alternative Names

MFGE8Lactadherin; BP47; Components 15/16; MFGM; MGP57/53; Milk fat globule-EGF factor 8; MFG-E8; PAS-6/PAS-7 glycoprotein; SED1; Sperm surface protein SP47

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

19-427

Target Protein Sequence

AS GDFCDSSLCL HGGTCLLNED RTPPFYCLCP EGFTGLLCNE TEHGPCFPNP CHNDAECQVT DDSHRGDVFI QYICKCPLGY VGIHCETTCT SPLGMQTGAI ADSQISASSM HLGFMGLQRW APELARLHQT GIVNAWTSGN YDKNPWIQVN LMRKMWVTGV VTQGASRAGS AEYLKTFKVA YSTDGRQFQF IQVAGRSGDK IFIGNVNNSG LKINLFDTPL ETQYVRLVPI ICHRGCTLRF ELLGCELNGC TEPLGLKDNT IPNKQITASS YYKTWGLSAF SWFPYYARLD NQGKFNAWTA QTNSASEWLQ IDLGSQKRVT GIITQGARDF GHIQYVAAYR VAYGDDGVTW TEYKDPGASE SKIFPGNMDN NSHKKNIFET PFQARFVRIQ PVAWHNRITL RVELLGC
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Contributes to phagocytic removal of apoptotic cells in many tissues. Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction.

Gene References into Functions

The vesicular environment provides optimal conditions for presentation and recognition of phosphatidylserine by lactadherin in a simple binding mechanism. PMID:21920348
lactophorin C-terminal fragment (LP16) and bovine milk fat globule membrane protein PAS6/7 strongly inhibited the replication of human rotavirus replication PMID:20622446
Lactadherin inhibits enzyme complexes of blood coagulation by competing for phospholipid-binding sites. PMID:12517809
The number of lactadherin binding sites increased proportionally to the phosphatidylserine content over a range 0-2% and less rapidly for higher phosphatidylserine content PMID:15533308
The crystal structure of the bovine lactadherin C2 domain (residues 1 to 158) at 2.4 A, was determined. PMID:17583728
analysis of membrane-interactive loops of Lact-C2 PMID:18160406
angiogenic endothelial cells have phagocytic properties for lactadherin-opsonized large particles and apoptotic cells PMID:18292292