Recombinant Bovine Kininogen-1 (KNG1), partial

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MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

KNG1

Uniprot NO.

P01044

Alternative Names

KNG1; Kininogen-1; Kininogen I; Thiol proteinase inhibitor) [Cleaved into: Kininogen-1 heavy chain; Bradykinin; Kallidin I); Lysyl-bradykinin; Kallidin II); Kininogen-1 light chain]

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

19-621

Target Protein Sequence

QE SSQEIDCNDQ DVFKAVDAAL TKYNSENKSG NQFVLYRITE VARMDNPDTF YSLKYQIKEG DCPFQSNKTW QDCDYKDSAQ AATGECTATV AKRGNMKFSV AIQTCLITPA EGPVVTAQYE CLGCVHPIST KSPDLEPVLR YAIQYFNNNT SHSHLFDLKE VKRAQRQVVS GWNYEVNYSI AQTNCSKEEF SFLTPDCKSL SSGDTGECTD KAHVDVKLRI SSFSQKCDLY PVKDFVQPPT RLCAGCPKPI PVDSPDLEEP LSHSIAKLNA EHDGAFYFKI DTVKKATVQV VAGLKYSIVF IARETTCSKG SNEELTKSCE INIHGQILHC DANVYVVPWE EKVYPTVNCQ PLGQTSLMKR PPGFSPFRSV QVMKTEGSTT VSLPHSAMSP VQDEERDSGK EQGPTHGHGW DHGKQIKLHG LGLGHKHKHD QGHGHHGSHG LGHGHQKQHG LGHGHKHGHG HGKHKNKGKN NGKHYDWRTP YLASSYEDST TSSAQTQEKT EETTLSSLAQ PGVAITFPDF QDSDLIATVM PNTLPPHTES DDDWIPDIQT EPNSLAFKLI SDFPETTSPK CPSRPWKPVN GVNPTVEMKE SHDFDLVDAL L
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

Gene References into Functions

Bradykinin, together with its precursor and tissue kallikrein, is continuously released into the vasculature of the isolated, perfused, lactating bovine udder. PMID:12181294
Bradykini stimulates endothelial cell fatty acid oxidation by calmodulin-dependent kinase kinase -dependent activation of AMP-activated protein kinase (AMPK) PMID:18191860

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Subcellular Location

Secreted, extracellular space.

Tissue Specificity

Plasma.

Database Links

UNIGENE: Bt.4210

STRING: 9913.ENSBTAP00000048995

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