This IL-8 (CXCL8) protein is a semi-custom product. There are 5 expression system options: Yeast, E. coli, In Vivo Biotinylation in E. coli, Baculovirus, and Mammalian cell. Your requirements will be given top priority in determining the protein tags. For proteins within 800 aa, risk-free custom service is guaranteed. It means you will not be charged if the protein cannot be delivered.
IL-8, also called CXCL8, is a chemokine crucial in various physiological and pathological processes. Initially recognized for its leukocyte chemotactic properties, CXCL8 has been found to have tumorigenic and proangiogenic effects [1]. It acts as a multifunctional cytokine influencing tumor proliferation, invasion, and migration in both autocrine and paracrine manners [2]. CXCL8 mediates its activities by binding to two G protein-coupled receptors, CXCR1 and CXCR2 [3].
CXCL8 promotes tumor proliferation, migration, and invasion [4]. It is a potent chemoattractant for neutrophils, myeloid-derived suppressor cells (MDSCs), and monocytes, which are components associated with immunosuppression in cancer [5]. CXCL8 regulates dendritic cell activation markers and recruitment, indicating its role in the immune response against colorectal cancer [5].
For inflammatory responses, CXCL8 is known to guide neutrophils through tissue matrices to injury sites, showcasing its role as a potent chemoattractant molecule [6]. Furthermore, CXCL8 has been linked to neutrophil recruitment, activation, and the release of neutrophil extracellular traps (NETs) in severe COVID-19 cases, contributing to inflammation and organ dysfunction [7].
References:
[1] D. Brat, A. Bellail, & E. Meir, The role of interleukin-8 and its receptors in gliomagenesis and tumoral
angiogenesis, Neuro-Oncology, vol. 7, no. 2, p. 122-133, 2005. https://doi.org/10.1215/s1152851704001061
[2] Q. Liu, A. Li, Y. Tian, J. Wu, Y. Liu, T. Liet al., The cxcl8-cxcr1/2 pathways in cancer, Cytokine & Growth Factor Reviews, vol. 31, p. 61-71, 2016. https://doi.org/10.1016/j.cytogfr.2016.08.002
[3] N. Zhang, Serum cxcl8 and cxcr2 as diagnostic biomarkers for noninvasive screening of cervical cancer, Medicine, vol. 102, no. 34, p. e34977, 2023. https://doi.org/10.1097/md.0000000000034977
[4] J. Li, Q. Liu, X. Huang, Y. Cai, S. Li, Q. Xieet al., Transcriptional profiling reveals the regulatory role of cxcl8 in promoting colorectal cancer, Frontiers in Genetics, vol. 10, 2020. https://doi.org/10.3389/fgene.2019.01360
[5] E. Li, X. Yang, Y. Du, G. Wang, D. Chan, D. Wuet al., Cxcl8 associated dendritic cell activation marker expression and recruitment as indicators of favorable outcomes in colorectal cancer, Frontiers in Immunology, vol. 12, 2021. https://doi.org/10.3389/fimmu.2021.667177
[6] S. Oliveira, C. Reyes-Aldasoro, S. Candel, S. Renshaw, V. Mulero, & Â. Calado, Cxcl8 (il-8) mediates neutrophil recruitment and behavior in the zebrafish inflammatory response, The Journal of Immunology, vol. 190, no. 8, p. 4349-4359, 2013. https://doi.org/10.4049/jimmunol.1203266
[7] M. Cesta, M. Zippoli, C. Marsiglia, E. Gavioli, G. Cremonesi, A. Khanet al., Neutrophil activation and neutrophil extracellular traps (nets) in covid‐19 ards and immunothrombosis, European Journal of Immunology, vol. 53, no. 1, 2022. https://doi.org/10.1002/eji.202250010
