Recombinant Bovine Interferon beta-1 (IFNB1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

IFNB1

Uniprot NO.

P01578

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

22-186

Target Protein Sequence

RSYSLLRFQ QRQSLKECQK LLGQLPSTSQ HCLEARMDFQ MPEEMKQEQQ FQKEDAILVM YEVLQHIFGI LTRDFSSTGW SETIIEDLLK ELYWQMNRLQ PIQKEIMQKQ NSTTEDTIVP HLGKYYFNLM QYLESKEYDR CAWTVVQVQI LTNVSFLMRL TGYVRD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Has antiviral, antibacterial and anticancer activities.

Gene References into Functions

BVDV2-E significantly increased IFN-beta activity compared to BVDV2-wt. PMID:28432927
The data confirm the involvement of EHMT2 in the epigenetic regulation of IFN-b and demonstrate the activation of a general antiviral state after EHMT2 inhibition. PMID:26418342
The authors provide evidence that ICP27 protein encoded by bovine herpesvirus type 1, a viral early protein that shuttles between the nucleus and cytoplasm inhibits transcriptional activity of two bovine IFN-beta gene promoters (IFN-beta1 and IFN-beta3). PMID:22902481
The authors demonstrate that bovine herpesvirus 1 bICP0 effectively inhibits bovine IFN-beta promoter activity and induces IRF3 degradation. PMID:21689696
These studies provide evidence that virus infection differentially stimulates expression of the three bovine IFN-beta genes. PMID:21316405
recombinant bovine respiratory syncytial virus lacking the NS proteins, and those lacking NS2 in particular, are strong inducers of IFN-alpha/beta in bovine nasal fibroblasts and bronchoalveolar macrophages. PMID:12857912