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Recombinant Bovine Insulin-like growth factor-binding protein 3 (IGFBP3)

Recombinant Bovine Insulin-like growth factor-binding protein 3 (IGFBP3)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

IGFBP3

Uniprot NO.

P20959

Alternative Names

IGFBP3; Insulin-like growth factor-binding protein 3; IBP-3; IGF-binding protein 3; IGFBP-3

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

28-291

Target Protein Sequence

GAG TMGAGPVVRC EPCDARAVAQ CAPPPPSPPC AELVREPGCG CCLTCALREG QPCGVYTERC GSGLRCQPPP GDPRPLQALL DGRGLCANAS AVGRLRPYLL PSASGNGSES EEDHSMGSTE NQAGPSTHRV PVSKFHPIHT KMDVIKKGHA KDSQRYKVDY ESQSTDTQNF SSESKRETEY GPCRREMEDT LNHLKFLNML SPRGIHIPNC DKKGFYKKKQ CRPSKGRKRG FCWCVDKYGQ PLPGFDVKGK GDVHCYSMES K
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Promotes testicular germ cell apoptosis.

Gene References into Functions

The study demonstrates that hyaluronan acts as an anti-inflammatory molecule by down-regulating IFNAR1 and IFNAR2, the signaling molecules STAT1, STAT2, JAK1 and the downstream apoptotic targets IGFBP3 and IFIT3. PMID:28003146
These data suggest that endogenous IGFBP-3 plays a role in intrinsic apoptosis by facilitating phosphorylation and nuclear export of Nur77 to the cytoplasm where it exerts its apoptotic effect. PMID:26340041
The present study suggests that the insulin like growth factor (IGF) system or imbalances between IGF and IGF binding proteins may be involved in cystic ovary disease of cattle. PMID:21940120
spatial and temporal patterns of expression of IGFBP-2 and -3 were markedly altered in the placentomes of nuclear transfer pregnancies PMID:14561651
stimulation of IGFBP-3 mRNA levels by mitogens is regulated through both the PI3K and MAPK pathways in bovine mammary epithelial cells PMID:15192040
Preincubation of erythroid cells with thrombospondin 1 eliminated the inhibitory activity of IGFBP-3 PMID:15927849
GH, IGF-I and IGF-IBP3 regulated the growth and development traits in different growth period. PMID:16870578
delivery of insulin-like growth factor-1 (IGF-1, delivered at concentrations of 0, 10, 50, and 100 ng/mL) affects the endogenous expression of IGF-1, its receptor (IGF-1R), and a well known IGF-1 binding protein (IGFBP-3) by articular chondrocytes PMID:18491951
Multivariable adjusted analyses did not reveal a statistically significant linear relationship between IGF1 or IGFBP3 concentrations or their molar ratio and risk of myocardial infarction PMID:18703768
Endogenous IGFBP-3 is required for both growth factor-stimulated cell proliferation and cytokine-induced apoptosis in mammary epithelial cells. PMID:19259947