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Recombinant Bovine Hormone-sensitive lipase (LIPE), partial

Recombinant Bovine Hormone-sensitive lipase (LIPE), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

LIPE

Uniprot NO.

P16386

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

1-756

Target Protein Sequence

MDLRTMTQSL VTLAEDNMAF FSSQGPGETA RRLTGVFAGI REQALGLEPA LGRLLSVAHL FDLDTETPAN GYRSLVHTAR CCLAHLLHKS RYVASNRRSI FFRTSHNLAE LEAYLAALTQ LRALAYYAQR LLTTNQPGRL FFEGDERVIA DFLREYVTLH KGCFYGRCLG FQFTPAIRPF LQTISIGLVS FGEHYKRNET GISVTASSLF TDGRFAIDPE LRGAEFERII QNLDVHFWKA FWNITEIQVL SSLANMASTT VRVSRLLSLP PVAFEMPLTS DPELTVTISP PLAHTGPGPV LVRLISYDLR EGQDSKELSS FVRSEGPRSL ELRLRPQQAP RSRALVVHIH GGGFVAQTSK SHEPYLKSWA QELGAPILSI DYSLAPEAPF PRALEECFYA YCWAVKHCAL LGSTGERICL AGDSAGGNLC FTVSLRAAAY GVRVPDGIMA AYPATMLQST ASPSRLLSLM DHLLPLSVLS KCVSTYAGAE TEDHPDSDQK ALGVMGLVQR DTALLLRDLR LGASSWLNSF LELGGQKSHL KSVSKTEPMR RSVSEAALTQ PEGSLGTDSL KSLKLHDLGL RNSSDTTDTP ELSLSAETLG PSAPSTINFL LGSEDGSEMS KAPEELNNKD RVRGVGAAFP EGFHPRRCSQ GAMWMPLYSA PIVKNPSMSP LLAPDSMLQT LPPVHIVACA LDPMLDDSVM FARRLRGLGQ PVTLRVAEDL PHGFLSLAAL CRETRQAAAL CVERIRLILN LPGPPV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters. Shows a preferential hydrolysis of DAGs over TAGs and MAGs. Preferentially hydrolyzes fatty acid (FA) esters at the sn-3 position of the glycerol backbone in DAGs and FA esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs. Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.

Gene References into Functions

Polymorphisms in HSL might be one of important genetic factors that influence carcass yield and meat quality in beef cattle. PMID:24213829
These results suggest that HSL was regulated by fatty acids and some hormones in mammary epithelial cells and thereby play an important role of lipid and energy metabolism. PMID:18755148

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Subcellular Location

Cell membrane. Membrane, caveola. Cytoplasm, cytosol. Lipid droplet.

Protein Families

'GDXG' lipolytic enzyme family

Database Links

UNIGENE: Bt.28410

KEGG: bta:286879

STRING: 9913.ENSBTAP00000041426

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