This Recombinant bovine hepatocyte growth factor (HGF) is a semi-custom product. There are 5 expression system options: Yeast, E. coli, In Vivo Biotinylation in E. coli, Baculovirus, and Mammalian cell. Your requirements will be given top priority in determining the protein tags. For proteins within 800 aa, risk-free custom service is guaranteed. It means you will not be charged if the protein cannot be delivered.
Hepatocyte growth factor (HGF) has a strong mitogenic effect on hepatocytes and is considered a hepatotrophic factor for hepatic regeneration [1-4]. HGF inhibits the growth of hepatocellular carcinoma cells and has potent anti-proliferative activity in various tumor cell lines [5][6]. Studies have shown that HGF protects against Fas-mediated liver apoptosis and has anti-apoptotic effects on hepatocytes [7][8]. HGF also regulates cell motility, cell growth, morphogenesis, and angiogenesis in various cell types [9]. Furthermore, HGF has been associated with poor prognosis in malignant gliomas and is a predictor for the recurrence of meningioma [3]. HGF is also a potent renotrophic factor for renal regeneration following acute renal failure [4].
References:
[1] N. Lokker, M. Mark, E. Luis, G. Bennett, K. Robbins, J. Bakeret al., Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding., The Embo Journal, vol. 11, no. 7, p. 2503-2510, 1992. https://doi.org/10.1002/j.1460-2075.1992.tb05315.x
[2] X. Gao, H. Mae, N. Ayabe, T. Takai, K. Oshima, M. Hattoriet al., Hepatocyte growth factor gene therapy retards the progression of chronic obstructive nephropathy, Kidney International, vol. 62, no. 4, p. 1238-1248, 2002. https://doi.org/10.1111/j.1523-1755.2002.kid579.x
[3] Ó. Arrieta, E. Garcı́a, P. Guevara, R. Garcia-Navarrete, R. Ondarza, D. Rembaoet al., Hepatocyte growth factor is associated with poor prognosis of malignant gliomas and is a predictor for recurrence of meningioma, Cancer, vol. 94, no. 12, p. 3210-3218, 2002. https://doi.org/10.1002/cncr.10594
[4] K. Sugimura, T. Kim, T. Goto, S. Kasai, Y. Takemoto, J. Matsudaet al., Serum hepatocyte growth factor levels in patients with chronic renal failure, Nephron, vol. 70, no. 3, p. 324-328, 1995. https://doi.org/10.1159/000188612
[5] G. Shiota, D. Rhoads, Y. Wang, T. Nakamura, & E. Schmidt, Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells., Proceedings of the National Academy of Sciences, vol. 89, no. 1, p. 373-377, 1992. https://doi.org/10.1073/pnas.89.1.373
[6] H. Tajima, K. Matsumoto, & T. Nakamura, Hepatocyte growth factor has potent anti‐proliferative activity in various tumor cell lines, Febs Letters, vol. 291, no. 2, p. 229-232, 1991. https://doi.org/10.1016/0014-5793(91)81291-f
[7] H. Suzuki, M. Toyoda, N. Horiguchi, S. Kakizaki, T. Ohyama, D. Takizawaet al., Hepatocyte growth factor protects against fas‐mediated liver apoptosis in transgenic mice, Liver International, vol. 29, no. 10, p. 1562-1568, 2009. https://doi.org/10.1111/j.1478-3231.2009.02102.x
[8] S. Motoi, H. Toyoda, T. Obara, E. Ohta, Y. Arita, K. Negishiet al., Anti-apoptotic effects of recombinant human hepatocyte growth factor on hepatocytes were associated with intrahepatic hemorrhage suppression indicated by the preservation of prothrombin time, International Journal of Molecular Sciences, vol. 20, no. 8, p. 1821, 2019. https://doi.org/10.3390/ijms20081821
[9] Q. Jiang, E. Azuma, M. Tanaka, M. Kobayashi, M. Hirayama, T. Kumamotoet al., Differential responsiveness of cord and adult blood monocytes to hepatocyte growth factor, Clinical & Experimental Immunology, vol. 125, no. 2, p. 222-228, 2001. https://doi.org/10.1046/j.1365-2249.2001.01591.x
