Recombinant Bovine Haptoglobin (HP)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Purity

>85% (SDS-PAGE)

Target Names

Uniprot NO.

Q2TBU0

Alternative Names

HPHaptoglobin [Cleaved into: Haptoglobin alpha chain; Haptoglobin beta chain]

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

19-401

Target Protein Sequence

VE TGSEATADSC PKAPEIANSH VEYSVRYQCD KYYKLHAGNG VYTFNNKQWI NKDIGQQLPE CEEDDSCPEP PKIENGYVEY LVRYQCKPYY TLRTCGDGVY TFNSKKQWIN KNIGQKLPEC EAVCGKPKHP VDQVQRIIGG SLDAKGSFPW QAKMVSQHNL ISGATLINER WLLTTAKNLY LGHSSDKKAK DITPTLRLYV GKNQLVEVEK VVLHPDHSKV DIGLIKLRQK VPVNDKVMPI CLPSKDYVKV GRVGYVSGWG RNENFNFTEH LKYVMLPVAD QDKCVKHYEG VDAPKNKTAK SPVGVQPILN ENTFCVGLSK YQDDTCYGDA GSAFVVHDKE DDTWYAAGIL SFDKSCAVAE YGVYVKVTSI LDWVRKTIAN N
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.

Gene References into Functions

These results indicate that it is possible to monitor the course of pyometra in cows based on the evaluation of the concentration of cytokines and Hp in the serum and uterine washings. PMID:25704413
These data demonstrate that serum neutrophil haptoglobin-MMP 9 complexes appear sooner and decline more rapidly than other acute phase proteins. PMID:25358728
An increase in serum amyloid A or haptoglobin in dairy cows with abomasal displacementis not specific for inflammation or bacterial infection; increased levels of either may indicate the presence of hepatic lipidosis. PMID:20391639
Haptoglobin concentration may be a useful indicator for cows with postpartum reproductive disorders. PMID:14960809
Presence in the milk of the acute phase proteins (APP), haptoglobin (Hp) and serum amyloid A to see the relationships in cow composite and bulk tank milk samples. PMID:17227596
Bovine granulocytes, isolated from peripheral blood of healthy cattle, contain abundant amounts of haptoglobin within the granules. PMID:17681384
This study suggests that neutrophils and epithelial cells may play an essential role in elevating milk haptoglobin (Hp) in addition to previous suggestions that Hp may be derived from mammary tissues and circulation. PMID:19094922